Results 31 to 40 of about 4,278 (174)
Characterization of the Effects of Semaphorin 4D Signaling on Angiogenesis. [PDF]
Methods Mol Biol, 2017 The semaphorins and plexins comprise a family of cysteine-rich cell surface and secreted proteins originally shown to control nerve growth and the immune response, but that have recently been implicated in a wide variety of developmental and pathological processes that are influenced by cell adhesion and migration.
Zhou H, Yang YH, Basile JR.
europepmc +4 more sources
Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor. [PDF]
Int J Mol Sci, 2021 Semaphorin 4D (Sema4D) is a neurotrophin that is secreted by osteoclasts and binds to its receptor PlexinB1 on osteoblasts to inhibit their differentiation and function.
Llamas-Granda P +4 more
europepmc +2 more sources
Medical Journal of Babylon, 2023 Background: Periodontal diseases are progressive, destructive, and inflammatory conditions of the tissues that support the teeth. An immune response is triggered by microbial dysbiosis in the sub-gingival biofilm. Semaphorin 4D (Sema4D) is a glycoprotein
Zahraa M Alwan, Ayser N Mohammed
doaj +1 more source
Association of Immune Semaphorins with COVID-19 Severity and Outcomes
Biomedicines, 2023 Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic +4 more
doaj +1 more source
Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D. [PDF]
Oncoimmunology, 2015 Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other ...
Evans EE, Paris M, Smith ES, Zauderer M.
europepmc +4 more sources
Biology and function of neuroimmune semaphorins 4A and 4D [PDF]
Immunologic Research, 2011 Semaphorins belong to a family of membrane-bound and secreted molecules that regulate the functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins also found to be expressed in immune cells and were, therefore, termed "immune semaphorins".
EusebiusHenry, Nkyimbeng-Takwi +1 more
openaire +2 more sources
Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. [PDF]
Int J Oncol, 2017 Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes.
Takada H +14 more
europepmc +3 more sources
Frontiers in Oral Health, 2022 Head and neck squamous cell carcinoma (HNSCC) can be classified according to the histological inflammatory subtype (HIS) into inflamed (HIS-INF) or immune excluded (HIS-IE).
Ioana Ghita +14 more
doaj +1 more source