Results 21 to 30 of about 4,062 (156)

Characterization of the Effects of Semaphorin 4D Signaling on Angiogenesis. [PDF]

Methods Mol Biol, 2017
The semaphorins and plexins comprise a family of cysteine-rich cell surface and secreted proteins originally shown to control nerve growth and the immune response, but that have recently been implicated in a wide variety of developmental and pathological processes that are influenced by cell adhesion and migration.
Zhou H, Yang YH, Basile JR.
europepmc   +4 more sources

Salivary Semaphorin 4D level in patients with different severities of periodontitis (observational case–control study)

Medical Journal of Babylon, 2023
Background: Periodontal diseases are progressive, destructive, and inflammatory conditions of the tissues that support the teeth. An immune response is triggered by microbial dysbiosis in the sub-gingival biofilm. Semaphorin 4D (Sema4D) is a glycoprotein
Zahraa M Alwan, Ayser N Mohammed
doaj   +1 more source

Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D. [PDF]

Oncoimmunology, 2015
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other ...
Evans EE, Paris M, Smith ES, Zauderer M.
europepmc   +4 more sources

Association of Immune Semaphorins with COVID-19 Severity and Outcomes

Biomedicines, 2023
Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic, Neven Papic, Lara Samadan, Mirjana Balen Topic, Adriana Vince   +4 more
doaj   +1 more source

Biology and function of neuroimmune semaphorins 4A and 4D [PDF]

Immunologic Research, 2011
Semaphorins belong to a family of membrane-bound and secreted molecules that regulate the functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins also found to be expressed in immune cells and were, therefore, termed "immune semaphorins".
EusebiusHenry, Nkyimbeng-Takwi, Svetlana P, Chapoval   +1 more
openaire   +2 more sources

Regulation of Vascular Calcification by M1-Type Macrophage-Derived Semaphorin 4D. [PDF]

Int J Mol Sci
Vascular calcification is a critical pathological hallmark of cardiovascular diseases. Although previous studies have indicated that M1 macrophages significantly promote calcification, the exact underlying mechanisms remain unclear. This study examined whether semaphorin 4D (Sema4D), a class IV semaphorin involved in atherosclerosis development, is ...
Park HJ, Kim Y, Kim MK, Kim HJ, Bae SK, Bae MK.   +5 more
europepmc   +3 more sources

Cytokine profiling in plasma distinguishes the histological inflammatory subtype of head and neck squamous cell carcinoma and a novel regulatory role of osteopontin

Frontiers in Oral Health, 2022
Head and neck squamous cell carcinoma (HNSCC) can be classified according to the histological inflammatory subtype (HIS) into inflamed (HIS-INF) or immune excluded (HIS-IE).
Ioana Ghita, Evangelia Piperi, Evangelia Piperi, Sergei P. Atamas, Soren M. Bentzen, Soren M. Bentzen, Soren M. Bentzen, Robert A. Ord, Robert A. Ord, Donita Dyalram, Donita Dyalram, Joshua E. Lubek, Joshua E. Lubek, Rania H. Younis, Rania H. Younis   +14 more
doaj   +1 more source

Semaphorins and Their Receptors in Hematological Malignancies

Frontiers in Oncology, 2019
While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei, Hongbo Li, Luca Tamagnone, Luca Tamagnone, Hua You, Hua You, Hua You   +6 more
doaj   +1 more source

Semaphorin 4D activates the MAPK pathway downstream of plexin‐B1 [PDF]

The FASEB Journal, 2006
Semaphorins are a large family of transmembrane and secreted proteins that signal primarily through the receptor, plexin. Semaphorins have been characterized in the nervous system as axon guidance cues, however they have also been shown to control development of other cellular systems such as the vasculature and lungs.
Jennifer, Aurandt, Weiquan, Li, Kun-Liang, Guan   +2 more
openaire   +2 more sources

Targeting Semaphorin 4D in Cancer: A Look from Different Perspectives [PDF]

Cancer Research, 2019
Abstract Semaphorin 4D (Sema4D) plays a role in various cell types including B lymphocytes, differentiating neurons, endothelial cells, and cancer cells. Preclinical and in vitro studies have shown that Sema4D-directed antibodies in combination with immune checkpoint inhibitors reshape the tumor microenvironment by promoting recruitment ...
Luca Tamagnone, Giulia Franzolin
openaire   +2 more sources