Journal of Indian Society of PeriodontologyBackground: Salivary biomarkers have the potential to be used as diagnostic tools for periodontal disease. This study aimed to evaluate the role of semaphorin 4D (SEMA4D) in saliva among healthy and periodontitis subjects and its response to nonsurgical ...
Bela Nagasmal Khobragade +4 more
doaj +2 more sources
Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients [PDF]
Journal of Bone Oncology, 2019 Background: Semaphorin 4D (Sema4D) is a glycoprotein that inhibits bone formation and has been associated with cancer progression and the occurrence of bone metastases.
Andy Göbel +11 more
doaj +2 more sources
Neoplasia: An International Journal for Oncology Research, 2017 The semaphorins and the plexins are a family of large, cysteine-rich proteins originally identified as regulators of axon growth and lymphocyte activation that are now known to provide motility and positional information for a number of cell and tissue ...
Hua Zhou +6 more
doaj +2 more sources
Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke [PDF]
MedicinaBackground and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli +2 more
doaj +2 more sources
Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study. [PDF]
Nutrients, 2023 International audienceBariatric surgery induces bone loss, but the exact mechanisms by which this process occurs are not fully known. The aims of this 2-year longitudinal study were to (i) investigate the changes in areal bone mineral density (aBMD) and ...
Maïmoun L +13 more
europepmc +2 more sources
Semaphorin 4D is expressed constitutively by human eosinophils
Allergology International, 2015 Yukiko Hiraguchi +5 more
doaj +3 more sources
Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis. [PDF]
Int J Mol Sci, 2022 Effects of the antiosteoblastogenesis factor Semaphorin 4D (Sema4D), expressed by thrombin-activated platelets (TPs), on osteoblastogenesis, as well as osteoclastogenesis, were investigated in vitro.
Shindo S +13 more
europepmc +2 more sources
Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression. [PDF]
Angiogenesis, 2012 The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some neoplasms producing SEMA4D in a ...
Hua, Zhou +4 more
core +4 more sources
Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model. [PDF]
Int J Mol Sci, 2021 Rett syndrome is a neurodevelopmental disorder caused by mutations of the methyl-CpG binding protein 2 gene. Abnormal physiological functions of glial cells contribute to pathogenesis of Rett syndrome.
Mao Y +6 more
europepmc +2 more sources
Neurobiology of Disease, 2015 Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavioral ...
Amber L. Southwell +16 more
doaj +2 more sources