Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. [PDF]
PLoS ONE, 2016 Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for ...
Ying-Hua Yang +6 more
doaj +9 more sources
Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development [PDF]
Reproductive Biology and Endocrinology, 2007 Background Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form, which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor.
Goldman Shlomit +2 more
doaj +4 more sources
Regulation of semaphorin 4D expression and cell proliferation of ovarian cancer by ERalpha and ERbeta [PDF]
Brazilian Journal of Medical and Biological Research, 2017 Ovarian cancer is one of the most common malignancies in women. Semaphorin 4D (sema 4D) is involved in the progress of multiple cancers. In the presence of estrogen-like ligands, estrogen receptors (ERα and ERβ) participate in the progress of breast and ...
Y. Liu +7 more
doaj +3 more sources
Control of bone resorption by semaphorin 4D is dependent on ovarian function. [PDF]
PLoS ONE, 2011 Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal ...
Romain Dacquin +5 more
doaj +7 more sources
Overexpression of Semaphorin-3A and Semaphorin-4D in the Peripheral Blood from Newly Diagnosed Patients with Chronic Lymphocytic Leukemia [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2019 Background: Semaphorins play prominent roles in physiological and pathological processes such as vascular development, tumor growth and immune responses. Semaphorins have different roles in various kinds of cancers, but there is no study concerning their
Somayeh Parsa +7 more
doaj +4 more sources
Corrigendum to Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression [PDF]
Innate Immunity, 2020 doaj +5 more sources
Regulation of Vascular Calcification by M1-Type Macrophage-Derived Semaphorin 4D. [PDF]
Int J Mol SciVascular calcification is a critical pathological hallmark of cardiovascular diseases. Although previous studies have indicated that M1 macrophages significantly promote calcification, the exact underlying mechanisms remain unclear. This study examined whether semaphorin 4D (Sema4D), a class IV semaphorin involved in atherosclerosis development, is ...
Park HJ +5 more
europepmc +4 more sources
Targeting Semaphorin 4D in Cancer: A Look from Different Perspectives [PDF]
Cancer Research, 2019 Abstract Semaphorin 4D (Sema4D) plays a role in various cell types including B lymphocytes, differentiating neurons, endothelial cells, and cancer cells. Preclinical and in vitro studies have shown that Sema4D-directed antibodies in combination with immune checkpoint inhibitors reshape the tumor microenvironment by promoting recruitment ...
Luca Tamagnone, Giulia Franzolin
openaire +3 more sources
Estrogen-dependent proteolytic cleavage of semaphorin 4D and plexin-B1 enhances semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice. [PDF]
PLoS ONE, 2014 Around the fifth week after birth, the vaginal cavity in female mouse pups opens to the overlaying skin. This postnatal tissue remodeling of the genital tract occurs during puberty, and it largely depends upon hormonally induced apoptosis that mainly ...
Takuji Ito +11 more
doaj +4 more sources
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center
Cell Reports, 2017 Summary: Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here.
Hu Yan +13 more
doaj +2 more sources