Results 101 to 110 of about 2,835 (194)

Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression

Cellular Oncology, 2009
Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth ...
Guido Valente, Giuseppina Nicotra, Marisa Arrondini, Roberta Castino, Lorena Capparuccia, Maria Prat, Simonetta Kerim, Luca Tamagnone, Ciro Isidoro   +8 more
doaj   +1 more source

Sema4D promotes larger metastatic lesions, with fewer osteoblasts and more osteoclasts.

, 2016
A. Hematoxylin and eosin (H&E) stained sections of control (C) tumors or those with silenced Sema4D (Sema4D shRNA) metastatic to the femur (top row; T, tumor; BM, bone marrow; original magnification 10x).
Hua Zhou (50017), Ying-Hua Yang (341730), Asma Buhamrah (2513161), Abraham Schneider (222540), Yi-Ling Lin (63628), Amr Bugshan (2513158), John R. Basile (341733)   +6 more
core   +1 more source

Silencing Sema4D in breast cancer changes serum levels of mediators of bone remodeling.

, 2016
A. ELISA performed for RANKL, an osteoblast-derived pro-osteoclastogenic factor, revealed higher levels in mice bearing tumors from MDA-MB-231 where Sema4D was silenced, suggestive of enhanced osteoblast activity, when compared to controls (RANKL levels ...
Hua Zhou (50017), Ying-Hua Yang (341730), Asma Buhamrah (2513161), Abraham Schneider (222540), Yi-Ling Lin (63628), Amr Bugshan (2513158), John R. Basile (341733)   +6 more
core   +1 more source

Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat

Disease Models & Mechanisms, 2014
Most spinal cord injuries lead to permanent paralysis in mammals. By contrast, the remarkable regenerative abilities of salamanders enable full functional recovery even from complete spinal cord transections.
Juan Felipe Diaz Quiroz, Eve Tsai, Matthew Coyle, Tina Sehm, Karen Echeverri   +4 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Establishment of a sandwish ELISA to measure soluble Sema4D in human plasma.

, 2013
A. pSecTag2B plasmid containing His-tagged Sema4D coding sequence for amino acids 1–734 was expressed in HEK293T cells. His-tagged Sema4D in the conditioned medium was purified by affinity chromatography.
Xin Zhao (71840), Haibo Gu (417268), Qingyu Wu (147511), Shengjie Zhang (417267), Qi Wang (22418), Li Zhu (67404), Ningzheng Dong (328283), Yuxin Wang (414197), Wenxiu Yi (417266), Qiongyu Lu (417265), Boquan Jin (383395), Lawrence F. Brass (417270), Xiaorong Tang (417269)   +12 more
core   +1 more source

Abstract LB-36: Antibody mediated neutralization of sema4D reduces tumor angiogenesis and growth In Vivo.

, 2010
It has been demonstrated that semaphorin 4D (SEMA4D; CD100) is a potent pro-angiogenic molecule. SEMA4D binding to its receptor plexin-B1 (PLXNB1) on endothelial cells transactivates c-MET and promotes formation of new blood vessels and tumor growth in ...
Renee Kirk, Ernest S. Smith, John E. Leonard, Laurie Winter, Patrick Kenney, Alan Howell, Mark Paris, Maria Scrivens, Christine Reilly, Jeff Caplan, Terrance Fisher, Sebold Torno, Alan Jonason, Raymond Watkins, Maurice Zauderer, Elizabeth Evans, Ji Li, Holm Bussler   +17 more
core   +1 more source

Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.

, 2010
Although semaphorins were-originally identified as axonal guidance molecules during neuronal development, it is emerging that several semaphorins play crucial roles in various phases of immune responses.
Nojima, S., Sakoda, S., Kumanogoh, A., Moriya, M., Nakagawa, Y., Kikutani, H., Okuno, T., Nakatsuji, Y., Takegahara, N., Kang, S., Takamatsu, H., Toyofuku, T., Friedel, R.H.   +12 more
core   +1 more source

Supplemental Methods from Nonclinical Safety Evaluation of VX15/2503, a Humanized IgG4 Anti-SEMA4D Antibody

, 2015
Supplemental Methods: Nonclinical Safety Evaluation of VX15/2503; a Humanized IgG4 Anti-SEMA4D ...
Ernest S. Smith (13209525), Laurie A. Winter (14999519), Chad A. Cornelius (15066841), Christine Reilly (13209522), John E. Leonard (14999510), Terrence L. Fisher (14999516), Maurice Zauderer (5681258)   +6 more
core   +1 more source

Study on the expression patterns and biological functions of oar-miR-214_3p in the ovary and uterus of Liangshan Black Sheep

Czech Journal of Animal Science
This study elucidates the expression dynamics and biological functions of oar-miR-214_3p in ovarian and uterine tissues of Liangshan Black Sheep across distinct stages of the oestrous cycle, providing novel insights into its regulatory mechanisms ...
Weihua Chang, Fengjiao Qiu, Shanchuan Liu, Guochao Ni, Ying Zhao, Yi Zhang, Guanwen Yan, Juanhong Wang   +7 more
doaj   +1 more source