Results 21 to 30 of about 2,413 (124)

SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling

Journal of Translational Medicine, 2022
Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. SEMA4D is a 150 kDa transmembrane protein that belongs to the IV class of the subfamily of semaphorin family.
Lu Liu, Lin Yang, Xiaojun Liu, Menghan Liu, Jing Liu, Xuefeng Feng, Ziyuan Nie, Jianmin Luo   +7 more
doaj   +1 more source

MIR4435-2HG, miR-125b-5p, and Sema4D axis affects the aggressiveness of colorectal cancer cells

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: The purpose of this study is to elucidate the impact of long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration.
Ming Yu, Zhengguo Yi, Shenghui Chen, Xiaopeng Chen, Xiaofeng Xie   +4 more
doaj   +1 more source

Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma

Autoimmunity, 2021
Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression.
Qiongyu Lu, Ping Cai, Yan Yu, Ziting Liu, Guona Chen, Zhao Zeng   +5 more
doaj   +1 more source

VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer

Cellular & Molecular Biology Letters, 2018
Background Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects.
Ying Chen, Lei Zhang, Wen-xin Liu, Ke Wang   +3 more
doaj   +1 more source

The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis

Frontiers in Endocrinology, 2018
Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity.
Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L. Galson, John M. Chirgwin, Attaya Suvannasankha   +5 more
doaj   +1 more source

Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw

European Journal of Medical Research, 2023
Background Bisphosphonates (BPs) are widely used in clinical practice to prevent and treat bone metabolism-related diseases. Medication-related osteonecrosis of the jaw (MRONJ) is one of the major sequelae of BPs use. Early prediction and intervention of
Hong Mu, Ying Pang, Lili Liu, Jingbo Liu, Chunsheng Liu   +4 more
doaj   +1 more source

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

Neurobiology of Disease, 2015
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration.
Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Michael Doherty, Ekaterina Klimatcheva, Crystal Mallow, Chad Cornelius, John E. Leonard, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, Maurice Zauderer   +23 more
doaj   +1 more source

Control of bone resorption by semaphorin 4D is dependent on ovarian function. [PDF]

PLoS ONE, 2011
Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal ...
Romain Dacquin, Chantal Domenget, Atsushi Kumanogoh, Hitoshi Kikutani, Pierre Jurdic, Irma Machuca-Gayet   +5 more
doaj   +1 more source

Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis

Frontiers in Immunology, 2020
ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
doaj   +1 more source

Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells

Dentistry Journal, 2023
This work aimed to evaluate the effect of Semaphorin 4D (SEMA4D) signaling through Plexin B1 on the vasculogenic differentiation of dental pulp stem cells.
Najla Al Turkestani, Zhaocheng Zhang, Jacques Eduardo Nör   +2 more
doaj   +1 more source