Results 21 to 30 of about 2,835 (194)

Regulatory role of neuronal guidance proteins in spinal cord injury [PDF]

Neural Regeneration Research
Spinal cord injury is a severe neurological condition with limited neuronal regeneration and functional recovery. Currently, no effective treatments exist to improve spinal cord injury prognosis.
Linyan Tang, Zhi Song, Jie Wang, Shenghua He, Chao Liu   +4 more
doaj   +2 more sources

Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages [PDF]

The Journal of Experimental Medicine, 2008
Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelial cells (Conrotto, P., D. Valdembri, S.
Sierra, Jose Rafael, Corso, Simona, Caione, Luisa, Cepero, Virna, Conrotto, Paolo, Cignetti, Alessandro, Piacibello, Wanda, Kumanogoh, Atsushi, Kikutani, Hitoshi, Comoglio, Paolo Maria, Tamagnone, Luca, Giordano, Silvia   +11 more
openaire   +4 more sources

The Role of Immune Semaphorins in Sepsis—A Prospective Cohort Study [PDF]

Microorganisms
In sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival.
Branimir Gjurasin, Lara Samadan Markovic, Leona Radmanic Matotek, Neven Papic   +3 more
doaj   +2 more sources

In Situ Endothelialization Promoted by SEMA4D and CXCL12 for Titanium-Based Biomaterials

Seminars in Thrombosis and Hemostasis, 2017
AbstractIn situ endothelialization, aiming to create implantation surfaces capable of self-endothelialization, seems to be an extremely promising solution, particularly on those blood-contacting surfaces. In this research study, we immobilized the soluble semaphorin 4D (SEMA4D) and C-X-C motif chemokine ligand 12 (CXCL12) biomolecules together with ...
Yuanyuan, Cui, Feng, Zhou, Lai, Wei, Qiang, Song, Jianying, Tan, Zheng, Zeng, Junying, Chen, Nan, Huang   +7 more
openaire   +3 more sources

Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring [PDF]

Nature Communications
Disruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various transcription factors such as Satb2 that control target genes during strict time windows.
Paraskevi Bessa, Andrew G. Newman, Kuo Yan, Theres Schaub, Rike Dannenberg, Denis Lajkó, Julia Eilenberger, Theresa Brunet, Kathrin Textoris-Taube, Emanuel Kemmler, Penghui Deng, Priyanka Banerjee, Ethiraj Ravindran, Robert Preissner, Marta Rosário, Victor Tarabykin   +15 more
doaj   +2 more sources

Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching [PDF]

Journal of Advanced Research
Introduction: Sympathetic hyperinnervation plays an important role in modulating the vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in abdominal aortic aneurysm (AAA) is still unknown.
Zhenquan Tang, Jingfang Xie, Ming Jin, Guoquan Wei, Ziwei Fu, Xiajing Luo, Chuling Li, Xiaoqian Jia, Hao Zheng, Lintao Zhong, Xinzhong Li, Junfen Wang, Guojun Chen, Yanmei Chen, Wangjun Liao, Yulin Liao, Jianping Bin, Senlin Huang   +17 more
doaj   +2 more sources

Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway [PDF]

PeerJ, 2023
Melanoma is a common skin tumor that causes a high rate of mortality, especially in Europe, North America and Oceania. Immunosuppressants such as anti-PD-1 have been used in the treatment of malignant melanoma, however, nearly 60% of patients do not ...
Zhuo Zhang, Duoli Zhang, Fang Wang, Jiao Liu, Yuhong Sun, Songyot Anuchapreeda, Singkome Tima, Zhangang Xiao, Suwit Duangmano   +8 more
doaj   +2 more sources

Leptin and melatonin’s effects on OVX rodents’ bone metabolism

Frontiers in Endocrinology, 2023
PurposeThis study aims to examine the effects of leptin and melatonin intervention on bone metabolism in ovariectomize (OVX) rodents, as well as their potential mechanisms of action.MethodsPrepare an OVX model of osteoporosis in rodents and validate the ...
Zhenen Lin, Guanshu Yu, Shengren Xiong, Yu Lin, Zhaohui Li   +4 more
doaj   +1 more source

Soluble Sema4D Level Is Positively Correlated with Sema4D Expression in PBMCs and Peripheral Blast Number in Acute Leukemia

Disease Markers, 2022
Semaphorin 4D (Sema4D) is highly expressed in various cancers and leukemia. It is involved in the development of acute leukemia. A high level of soluble Sema4D is also present in the plasma of acute leukemia patients. However, it remains unknown whether Sema4D is associated with the clinical characteristics of acute leukemia.
Li Xue, Shulan Shi, Hongtao Lei, Zhen Zhang, Xin Tian, Lijuan Qiu, Jiaolian Tang, Liyue Kui, Weiwei Nan, Xiaoyue Cao, Qiangming Sun, Ming Yu, Hongchao Jiang   +12 more
openaire   +2 more sources

SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling

Journal of Translational Medicine, 2022
Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. SEMA4D is a 150 kDa transmembrane protein that belongs to the IV class of the subfamily of semaphorin family.
Lu Liu, Lin Yang, Xiaojun Liu, Menghan Liu, Jing Liu, Xuefeng Feng, Ziyuan Nie, Jianmin Luo   +7 more
doaj   +1 more source