Results 11 to 20 of about 2,835 (194)

Roles of Sema4D and Plexin-B1 in tumor progression [PDF]

Molecular Cancer, 2010
Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories.
Ewe Seng Ch’Ng, Atsushi Kumanogoh, Ch'Ng Ewe Seng   +2 more
exaly   +7 more sources

Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression

Pharmacological Research, 2023
Liver fibrosis can occur in many chronic liver diseases, and no effective treatments are available due to the poorly characterized molecular pathogenesis. Semaphorin 4D (Sema4D) has immune functions and serves important roles in T cell priming.
Lifu Wang, Dinghao Li, Zifeng Zhu, Yao Liao, Ji Wu, Yuheng Liu, Ruibing Yang, Hanqiao Dai, Zhongdao Wu, Xi Sun   +9 more
doaj   +4 more sources

Increased levels of plasma soluble Sema4D in patients with heart failure. [PDF]

PLoS ONE, 2013
Semaphorin 4D (Sema4D/CD100) is a 150-kDa transmembrane glycoprotein expressed by platelets and T-cells. When these cells are activated, Sema4D is cleaved proteolytically, generating a biologically active 120-kDa fragment (soluble Sema4D) capable of ...
Qiongyu Lu, Ningzheng Dong, Qi Wang, Wenxiu Yi, Yuxin Wang, Shengjie Zhang, Haibo Gu, Xin Zhao, Xiaorong Tang, Boquan Jin, Qingyu Wu, Lawrence F Brass, Li Zhu   +12 more
doaj   +6 more sources

Impact of leptin or melatonin on Sema4D overexpression-related bone metabolism

Journal of Orthopaedic Surgery and Research, 2023
Purpose The current study aims to investigate the regulatory impact of leptin or melatonin on bone metabolism as well as the underlying mechanism in conjunction with Sema4D (monoclonal antibody to semaphorin 4D).
Zhenen Lin, Shengren Xiong, Yu Lin, Zhaohui Li, Dan Xie, Xuchao Lin, Xuesheng Chen, Xueyi Lin   +7 more
doaj   +4 more sources

Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes [PDF]

Nature Communications
Age-related macular degeneration (AMD) is a prevalent neuroinflammation condition and the leading cause of irreversible blindness among the elderly population. Smoking significantly increases AMD risk, yet the mechanisms remain unclear.
Kai He, Xue Dong, Tianjing Yang, Ziqi Li, Yuming Liu, Jing He, Meng Wu, Selena Wei-Zhang, Parhat Kaysar, Bohao Cui, Xueming Yao, Li Zhang, Wei Zhou, Heping Xu, Jun Wei, Qiang Liu, Junhao Hu, Xiaohong Wang, Hua Yan   +18 more
doaj   +3 more sources

MIR4435-2HG, miR-125b-5p, and Sema4D axis affects the aggressiveness of colorectal cancer cells

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: The purpose of this study is to elucidate the impact of long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration.
Ming Yu, Zhengguo Yi, Shenghui Chen, Xiaopeng Chen, Xiaofeng Xie   +4 more
doaj   +3 more sources

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

Neurobiology of Disease, 2015
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration.
Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Michael Doherty, Ekaterina Klimatcheva, Crystal Mallow, Chad Cornelius, John E. Leonard, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, Maurice Zauderer   +23 more
doaj   +2 more sources

A Novel Role for the Semaphorin Sema4D in the Induction of Allo-responses

Biology of Blood and Marrow Transplantation, 2007
Sema4D (CD100), a member of the neuro-semaphorin family of proteins, has recently been shown to play a role in modulating certain immune responses. We tested the requirement of Sema4D expression on T cells in the induction of T cell allo-immune responses.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ( host institution ), Duran-Struuck, Raimon, Tawara, Isao, Lowler, Kathi, Clouthier, Shawn G., Weisiger, Elizabeth, Rogers, Clare, Luker, Gary, Kumanogoh, Atsushi, Liu, Chen, Ferrara, James L.M., Reddy, Pavan   +11 more
openaire   +4 more sources

Inhibition of RANKL and Sema4D improves residual ridge resorption in mice [PDF]

Scientific Reports, 2022
Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments and leads to the pathogenesis of various systemic diseases.
Meri Hisamoto, Shunsuke Kimura, Kai Iwata, Toshihiko Iwanaga, Atsuro Yokoyama   +4 more
doaj   +5 more sources

METTL1 Aggravates Periodontitis Progression by Inhibiting Osteoblast Differentiation via m7G modification of SEMA4D [PDF]

International Dental Journal
Objective: Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Methyltransferase-like 1 (METTL1), a
Yong-Song Huang, Zi-Hao Zhang, Mei-Yun Zhou, Lin-Ya Geng, Ting-Ting Wang   +4 more
doaj   +2 more sources