Results 91 to 100 of about 2,098 (175)

Image_5_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Supplementary Figure 1 from Hormonal Regulation of Semaphorin 7a in ER⁺ Breast Cancer Drives Therapeutic Resistance

, 2021
SEMA7A predicts for outcome in ER+BC and SEMA7A expression is regulated by ...
Jennifer K. Richer (14946445), Taylor R. Rutherford (14946973), Lyndsey S. Crump (14932275), Weston W. Porter (8361093), Garhett L. Wyatt (14946970), Traci R. Lyons (6820022)   +5 more
core   +1 more source

SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front. [PDF]

Cancer Gene Ther
Tumor invasion is the hallmark of tumor malignancy. The invasive infiltration pattern of tumor cells located at the leading edge is highly correlated with metastasis and unfavorable patient outcomes. However, the regulatory mechanisms governing tumor malignancy at the invasive margin remain unclear.
Chen YI, Tien SC, Ko YL, Chang CC, Hsu MF, Chien HJ, Peng HY, Jeng YM, Tien YW, Chang YT, Chang MC, Hu CM.   +11 more
europepmc   +3 more sources

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Image_7_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

Investigating the role of Semaphorin7a in paracetamol induced liver injury [PDF]

, 2020
Paracetamol (Acetaminophen, APAP) overdose is responsible for 46% of drug induced liver injury in the Western world, causing 200 deaths in the UK and 500 deaths in the USA per annum. The current treatments for APAP overdose are NAcetyl-Cysteine, which is
Livingstone, Eilidh
core   +1 more source

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Nature Communications, 2017
The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via
Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J. C. G. M. Hellemons, Tianyi Mao, Paolo Giacobini, Henriette van Praag, Silvia De Marchis, Geert M. J. Ramakers, R. Jeroen Pasterkamp   +11 more
doaj   +1 more source

Image_4_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source