Results 71 to 80 of about 2,098 (175)

Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B [PDF]

International Journal of Ophthalmology
AIM: To evaluate the role of semaphorin 7A (Sema7A) and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells (HCEs).
Cheng-Cheng Yang, Xiu-Xia Yang, Xiao-Jing Zhao, Heng Wang, Zi-Han Guo, Kai Jin, Yang Liu, Bin-Hui Li   +7 more
doaj   +1 more source

Comparative Transcriptomics Reveals the Key lncRNA and mRNA of Sunite Sheep Adrenal Gland Affecting Seasonal Reproduction

Frontiers in Veterinary Science, 2022
The hypothalamic–pituitary–adrenal (HPA) axis plays an important role in the growth and development of mammals. Recently, lncRNA transcripts have emerged as an area of importance in sheep photoperiod and seasonal estrus studies.
Xiaolong Du, Xiaoyun He, Qiuyue Liu, Ran Di, Qingqing Liu, Qingqing Liu, Mingxing Chu   +6 more
doaj   +1 more source

Nanoplastics Impair GnRH Neuron Migration and Neuroendocrine Function: Emerging Players in the Pathogenesis of Reproductive Disorders

Small, Volume 22, Issue 15, 12 March 2026.
Little is known about the effects of polystyrene nanoplastics (PS‐NPs) on gonadotropin releasing hormone (GnRH) neurons, which control puberty onset and fertility. By applying tailored in vitro GnRH neuron models, this article shows how PS‐NPs are internalized and impact hormone secretion and cell migration, through gene expression changes. Ultimately,
Federica Amoruso, Alyssa Julia Jennifer Paganoni, Astrid Saraceni, Andrea Magnani, Alessia Brossa, Giorgio Roberto Merlo, Cristina Matei, Ruben Heinjan Willemsen, Raíssa Carneiro Rezende, Alexander Augusto de Lima Jorge, Federica Dal Bello, Patrizia Bovolin, Sasha Rose Howard, Roberto Oleari, Anna Cariboni   +14 more
wiley   +1 more source

Abstract 3438: Expression of a novel tumor-derived axonal guidance molecule Sema7a in a breast cancer model

, 2010
The purpose of this study is to explore the expression of axonal guidance molecule Sema7a by breast cancer cells and the possible hijacking of macrophages by Sema7a to promote tumor growth.
Stephania Libreros, Vijaya L. Iragavarapu-Charyulu, Ramon Garcia-Areas   +2 more
core   +1 more source

Image_8_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, Volume 13, Issue 10, 18 February 2026.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Image_2_Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.tif

, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Valbona Mirakaj (147976), David Köhler (147965), Claudia Eggstein (8553255), Peter Rosenberger (37609), Mariella Schneider (844737), Andreas Körner (17471865), Tiago F. Granja (17471871), Judith M. Roth (17471868)   +7 more
core   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, Volume 7, Issue 1, February 2026.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women [PDF]

Journal of Human Genetics, 2005
Bone mineral density (BMD), the major factor determining bone strength, is closely related to osteoporotic fracture risk and is determined largely by multiple genetic factors. Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the activation of monocyte/macrophages that share ...
Jung-Min, Koh, Bermseok, Oh, Jong Yong, Lee, Jong-Keuk, Lee, Kuchan, Kimm, Ghi Su, Kim, Byung Lae, Park, Hyun Sub, Cheong, Hyoung Doo, Shin, Jung Min, Hong, Tae-Ho, Kim, Eui Kyun, Park, Shin-Yoon, Kim   +12 more
openaire   +2 more sources

SEMA7A^-/- mice show attenuated pulmonary inflammation during lung injury.

, 2016
WT and SEMA7A-/- animals were exposed to either NaCl or LPS inhalation and the degree of inflammation was determined 4 hours later A) Cell counts and B) MPO activity in the BAL of WT and SEMA7A-/- mice. C) TNF-α D) IL-6 E) IL-1β F) CXCR2 G) KC and H) MIP-
Tiago Folgosa Granja (844738), David Köhler (147965), Peter Rosenberger (37609), Mariella Schneider (844737), Judith Marlene Roth (844736)   +4 more
core   +1 more source