Results 111 to 120 of about 1,907 (144)

Sema7A is a Potent Monocyte Stimulator [PDF]

Scandinavian Journal of Immunology, 2002
Sema7A is a recently described member of the semaphorin family that is associated with the cell surface via a glycophosphatidylinositol linkage. This study examined the mRNA expression and biological properties of this protein. Although the expression of Sema7A was demonstrated in lymphoid and myeloid cells, no stimulation of cytokine production or ...
S, Holmes, A M, Downs, A, Fosberry, P D, Hayes, D, Michalovich, P, Murdoch, K, Moores, J, Fox, K, Deen, G, Pettman, T, Wattam, C, Lewis   +11 more
exaly   +3 more sources

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SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming

Matrix Biology, 2023
Integrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the transduction of biochemical and biophysical microenvironment cues into cellular responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen their binding with the ECM, resulting in the assembly of force-resistant and force-sensitive integrin
Thomas Barker, Grace C Bingham, Mete Civelek   +2 more
exaly   +3 more sources

Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism [PDF]

Pediatric Research, 2014
Congenital hypogonadotropic hypogonadism (HH), a rare disorder characterized by absent, partial, or delayed puberty, can be caused by the lack or deficient number of hypothalamic gonadotropin-releasing hormone (GnRH) neurons. SEMA3A was recently implicated in the etiology of the disorder, and Sema7A-deficient mice have a reduced number of GnRH neurons ...
Jaakko Taneli Matinpoika Raivio, Peter Hackman, Taru Johanna Tommiska   +2 more
exaly   +4 more sources

SEMA7A: A glycoprotein with therapeutic potential in inflammatory diseases and tumor development

International Journal of Biological Macromolecules
Semaphorin 7a (SEMA7A), a GPI-anchored glycoprotein with dual neuroimmune functions, has emerged as pivotal regulator of neuroinflammatory and immunopathological processes. Its biological functions are primarily mediated by stereospecific interactions between the conserved SEMA domain and two distinct receptors: plexinC1 and β1-integrin.
Lixia Chen, Yueying Yang, Zhiruo Zhang   +2 more
exaly   +3 more sources

A new SEMA7A variant found in Native Americans with alloantibody

Vox Sanguinis, 2010
Background and Objectives  John Milton Hagen (JMH) antigens are carried by Semaphorin 7A that plays important roles in the nervous system and the immune responses. Its role on the erythrocytes is unclear. Over the years, few samples were referred to our Immunohaematology Reference Laboratory to elucidate their JMH status.Materials and Methods  Seven ...
M, Richard, J, St-Laurent, J, Perreault, A, Long, M, St-Louis   +4 more
openaire   +2 more sources

Sema7A and Sema4D Heterodimerization is Essential for Membrane Targeting and Neocortical Wiring

2023
SUMMARY Disruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various transcription factors such as Satb2 that control target genes during strict time windows.
Paraskevi Bessa, Andrew G. Newman, Kuo Yan, Theres Schaub, Rike Dannenberg, Denis Lajkó, Julia Eilenberger, Theresa Brunet, Kathrin Textoris-Taube, Emanuel Kemmler, Priyanka Banerjee, Ethiraj Ravindran, Michael Mülleder, Robert Preissner, Rudolf Grosschedl, Marta Rosário, Victor Tarabykin   +16 more
openaire   +1 more source

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1 [PDF]

Cell, 2010
Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding
Kenan Garcia, Xiaolin He, Heli Liu
exaly   +3 more sources

The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens

Transfusion, 2006
BACKGROUND: Semaphorin 7A (Sema7A), the protein that carries the JMH blood group antigen, is involved in immune responses and plays an important role in axon growth and guidance. Because previous serologic studies on red blood cells (RBCs) suggested a considerable diversity of Sema7A, the present study was designed to elucidate the complex picture of ...
Axel, Seltsam, Susanne, Strigens, Cyril, Levene, Vered, Yahalom, Marilyn, Moulds, John J, Moulds, Hein, Hustinx, Volker, Weisbach, Dolores, Figueroa, Christina, Bade-Doeding, David S, DeLuca, Rainer, Blasczyk   +11 more
openaire   +2 more sources

Differential expression of sema3A and sema7A in a murine model of multiple sclerosis: Implications for a therapeutic design

Clinical Immunology, 2016
We characterised the expression of semaphorin (sema)3A, sema7A and their receptors in the immune and the central nervous system (CNS) at different stages of experimental autoimmune encephalomyelitis (EAE). We also studied their expression in neonatal and adult oligodendrocyte progenitor cell (OPC) and in mature oligodendrocyte cultures.
Herena Eixarch, Mireia Castillo Juarez, Carme Costa   +2 more
exaly   +4 more sources

Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay

Transfusion, 2008
BACKGROUND: At present, identification of antibodies against the high‐prevalence JMH antigen is difficult and limited to reference laboratories having panels of rare red blood cell (RBC) specimens in stock. Here, a novel method is described for detection of anti‐JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that ...
Axel, Seltsam, Ashraf, Agaylan, Daniela, Grueger, Oliver, Meyer, Rainer, Blasczyk, Abdulgabar, Salama   +5 more
openaire   +2 more sources