The Role of Immune Semaphorins in Sepsis—A Prospective Cohort Study [PDF]
MicroorganismsIn sepsis, a balanced pro-inflammatory and anti-inflammatory response results in the bacterial clearance and resolution of inflammation, promoting clinical recovery and survival.
Branimir Gjurasin +3 more
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Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish [PDF]
eLifeIn a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize their terminal ...
Agnik Dasgupta +5 more
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DNA methylation markers of insulin resistance surrogate measures in the Atherosclerosis Risk in Communities (ARIC) study [PDF]
EpigeneticsInsulin resistance (IR) is a risk factor for cardiovascular diseases and type 2 diabetes. Associations between DNA methylation (DNAm) and IR have been less studied in African ancestry (AA) populations than those of European ancestry (EA).
Jeewoen Shin +8 more
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Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring [PDF]
Nature CommunicationsDisruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various transcription factors such as Satb2 that control target genes during strict time windows.
Paraskevi Bessa +15 more
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Sema7A is crucial for resolution of severe inflammation [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance Nonresolving inflammation, a hallmark of sepsis and/or multi-organ failure, still poses a challenge in medicine. The mortality rate is enormous, and so far no adequate curative therapy is available. Here we identify a previously unrecognized role of the neuronal guidance protein semaphorin 7A in the transition to ...
Körner, Andreas +7 more
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Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling
Frontiers in Immunology, 2023 IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Andreas Körner +7 more
doaj +1 more source
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Estrogen receptor-positive (ER+) breast cancers (BC) comprise >70% of all BC and cause the most BC-related deaths in women worldwide.
Rachel Steinmetz, Traci Lyons
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Multi-omics Mendelian randomization revealing SEMA7A as potential drug target for facial skin aging
Journal of Big DataBackground The study of facial skin aging has attracted significant attention not only for its esthetic implications but also for its potential to shed light on the mechanisms underlying the development of age-related diseases.
Xueyao Cai +4 more
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Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a
Cell Death and Disease, 2021 Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of ...
Taylor R. Rutherford +2 more
doaj +1 more source
457 Semaphorin7a expression in breast cancer promotes susceptibility to immune checkpoint blockade
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: The goal of this study is to decipher the mechanisms by which breast cancers evade the immune system to facilitate metastasis through the lymphatic vasculature.
Alan Elder +3 more
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