Results 11 to 20 of about 2,098 (175)

FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression

International Journal of Oral Science
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation has been intricately linked with immune escape and tumor growth. SEMA7A is a highly glycosylated protein with five glycosylated sites.
Xiaoyan Meng, Zhiyuan Zhang, Yue He
exaly   +5 more sources

Sema7a drives an immunosuppressive microenvironment of breast cancer via Kdm4a-mediated DNA replication regulation [PDF]

Communications Biology
Breast cancer remains a leading cause of cancer-related mortality worldwide, largely due to the persistence of an immunosuppressive tumor microenvironment that limits therapeutic efficacy.
Xianan Bai, Shanshan Cai, Jie Jiang, Maojin Tian, Jianxin Du, Peiqing Zhao   +5 more
doaj   +6 more sources

Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation [PDF]

Nature Communications, 2018
The molecular mechanisms underlying synapse formation in the olfactory bulb are not fully understood. Here the authors demonstrate that semaphorin 7A on olfactory sensory neurons, and its receptor plexin C1 expressed on mitral and tufted cells, is ...
Hirofumi Nishizumi, Hiroshi Kiyonari, Hitoshi Sakano   +2 more
exaly   +5 more sources

Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A [PDF]

International Journal of General Medicine
Lixian Yang,1,* Shiyu Zhang,1,* Lei Zheng,1 Fanting Kong,1 Wei Dang,2 Shipeng Shen,2 Xiaowei Li,1 Lining Jia,1 Xiaoru Zhang,1 Na Lu1 1Department of Breast Surgery, Xingtai People’s Hospital, Xingtai, Hebei, 054000, People’s Republic of China ...
Yang L, Zhang S, Zheng L, Kong F, Dang W, Shen S, Li X, Jia L, Zhang X, Lu N   +9 more
doaj   +4 more sources

Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling [PDF]

Biology Direct
Background & aims Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness.
Liankang Sun, Huanhuan Wang, Hanqi Li, Ruida Yang, Xuyuan Dong, Danfeng Dong, Yangwei Fan, Enxiao Li, Hao Wang, Yinying Wu, Yu Shi   +10 more
doaj   +3 more sources

SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer [PDF]

International Journal of General Medicine
Shiyu Zhang, Fanting Kong, Lei Zheng, Xiaowei Li, Lining Jia, Lixian Yang Department of Breast Surgery, Xingtai People’s Hospital, Xingtai, Hebei, 054000, People’s Republic of ChinaCorrespondence: Lixian Yang, Department of Breast Surgery, Xingtai People’
Zhang S, Kong F, Zheng L, Li X, Jia L, Yang L   +5 more
doaj   +4 more sources

Sema7A is crucial for resolution of severe inflammation [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Nonresolving inflammation, a hallmark of sepsis and/or multi-organ failure, still poses a challenge in medicine. The mortality rate is enormous, and so far no adequate curative therapy is available. Here we identify a previously unrecognized role of the neuronal guidance protein semaphorin 7A in the transition to resolution ...
Körner, Andreas, Bernard, Alice, Fitzgerald, Julia C., Alarcon-Barrera, Juan Carlos, Kostidis, Sarantos, Kaussen, Torsten, Giera, Martin, Mirakaj, Valbona   +7 more
openaire   +5 more sources

Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease [PDF]

BMC Pediatrics
Background Kawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been reported to regulate endothelial phenotypes associated with cardiovascular diseases, while its role in KD ...
Junhua Huang, Chuanmei Zhao, Shuwan Zhang   +2 more
doaj   +3 more sources

Bimodal Genomic Approach Predicting Semaphorin 7A (SEMA7A) as Prognostic Biomarker in Adrenocortical Carcinoma. [PDF]

Cancers (Basel)
Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with high mortality and poor prognosis. To elucidate the genetic underpinnings of ACCs, we have analyzed the transcriptome data of 112 ACC tumor samples from patients enrolled in the TCGA and NCI.
Dhall A, Taniyama D, Elloumi F, Luna A, Varma S, Kumar S, Escobedo L, Sun Y, Aladjem MI, Redon CE, Roper N, Reinhold WC, Del Rivero J, Pommier Y.   +13 more
europepmc   +6 more sources

Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling [PDF]

Frontiers in Immunology, 2023
IntroductionThe study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis.
Andreas Körner, David Köhler, Mariella Schneider, Judith M. Roth, Tiago F. Granja, Claudia Eggstein, Valbona Mirakaj, Peter Rosenberger   +7 more
doaj   +2 more sources