Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A [PDF]
International Journal of General MedicineLixian Yang,1,* Shiyu Zhang,1,* Lei Zheng,1 Fanting Kong,1 Wei Dang,2 Shipeng Shen,2 Xiaowei Li,1 Lining Jia,1 Xiaoru Zhang,1 Na Lu1 1Department of Breast Surgery, Xingtai People’s Hospital, Xingtai, Hebei, 054000, People’s Republic of China ...
Yang L +9 more
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SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer [PDF]
International Journal of General MedicineShiyu Zhang, Fanting Kong, Lei Zheng, Xiaowei Li, Lining Jia, Lixian Yang Department of Breast Surgery, Xingtai People’s Hospital, Xingtai, Hebei, 054000, People’s Republic of ChinaCorrespondence: Lixian Yang, Department of Breast Surgery, Xingtai People’
Zhang S +5 more
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International Journal of Oral ScienceSEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation has been intricately linked with immune escape and tumor growth. SEMA7A is a highly glycosylated protein with five glycosylated sites.
Yue He, Zhiyuan Zhang, Zhang Zhiyuan
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Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation [PDF]
Nature Communications, 2018 The molecular mechanisms underlying synapse formation in the olfactory bulb are not fully understood. Here the authors demonstrate that semaphorin 7A on olfactory sensory neurons, and its receptor plexin C1 expressed on mitral and tufted cells, is ...
Hitoshi Sakano +2 more
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Zfp462 Is a Key Mediator of Osteoblast Differentiation and Might Contribute to Age-Related Bone Loss. [PDF]
Aging CellOsteoblast‐specific Zfp462 deficiency reduces bone mass and strength, as well as the number of osteocalcin‐positive cells. Zfp462 forms a transcriptional complex with Moz and Runx2 to promote histone H3 acetylation and activate osteogenic gene expression.
Kim JM +11 more
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eLife, 2021 In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons.
Nobuko Inoue +6 more
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Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling [PDF]
Biology DirectBackground & aims Gallbladder cancer (GBC) is characterised by a desmoplastic microenvironment rich in collagen fibres and extracellular matrix, contributing to increased matrix stiffness.
Liankang Sun +10 more
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Serum Semaphorin Alterations in Psoriasis: Links to Metabolic Status Rather than Disease Severity [PDF]
MetabolitesIntroduction: Psoriasis is an autoimmune systemic disease of not entirely understood pathogenesis. It remains a significant therapeutic challenge and, due to its various comorbidities, has a remarkable detrimental effect on patients’ wellbeing ...
Anna Baran +6 more
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Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease [PDF]
BMC PediatricsBackground Kawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been reported to regulate endothelial phenotypes associated with cardiovascular diseases, while its role in KD ...
Junhua Huang +2 more
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The changes of immune function after neuroblastoma chemotherapy and the prediction of potential immune targets [PDF]
BMC Medical GenomicsBackground High-dose chemotherapy for neuroblastoma is often intolerable for children, and its effectiveness is difficult to determine. Immunotherapy has become a popular research focus as a potential treatment.
Yunfei Ma +8 more
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