Results 101 to 110 of about 372,053 (263)

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

Communications Chemistry
Semi-rational enzyme engineering is a powerful method to develop industrial biocatalysts. Profiting from advances in molecular biology and bioinformatics, semi-rational approaches can effectively accelerate enzyme engineering campaigns.
Sumire Honda Malca, Nadine Duss, Jasmin Meierhofer, David Patsch, Michael Niklaus, Stefanie Reiter, Steven Paul Hanlon, Dennis Wetzl, Bernd Kuhn, Hans Iding, Rebecca Buller   +10 more
doaj   +1 more source

Disulfide linkages in Plasmodium falciparum plasmepsin-i are essential elements for its processing activity and multi-milligram recombinant production yield.

PLoS ONE, 2014
Plasmodium falciparum plasmepsin-I (PM-I) has been considered a potential drug target for the parasite that causes fatal malaria in human. Determination of PM-I structures for rational design of its inhibitors is hindered by the difficulty in obtaining ...
Sirisak Lolupiman, Pilaiwan Siripurkpong, Jirundon Yuvaniyama   +2 more
doaj   +1 more source

Shaping Carbon Nitrides for Advanced Macrostructures

Advanced Materials Technologies, EarlyView.
This review examines how carbon nitride can be shaped through a range of printing and interfacial assembly methods. By bringing together additive manufacturing and liquid–liquid structuring concepts, carbon nitride is moving beyond its traditional powder‐based photocatalyst form toward digitally designed robust macroscale architectures with high design
Simona Baluchová, Baris Kumru
wiley   +1 more source

Thermal Stability Enhancement of L-Asparaginase from Corynebacterium glutamicum Based on a Semi-Rational Design and Its Effect on Acrylamide Mitigation Capacity in Biscuits. [PDF]

Foods, 2023
Chi H, Jiang Q, Feng Y, Zhang G, Wang Y, Zhu P, Lu Z, Lu F.   +7 more
europepmc   +1 more source

Voter Turnout in Direct Democracy: Theory and Evidence [PDF]

We analyse voter turnout as a function of referendum types. An advisory referendum produces advice that a legislature may or may not take into account when choosing between two alternatives, whereas a binding referendum generates a decisive decision.
Søberg, Morten, Tangerås, Thomas P.
core  

Substituent Effects on Cyanine Dyes Vary with Position and Chain Length

Advanced Optical Materials, EarlyView.
In cyanines, substituent effects vary as a function of substituent position and cyanine length. Electron‐donating‐ and ‐withdrawing groups at meso‐ and α‐positions of 4n+1/4n−1 long cyanines (n = 1, 2, 3…) cause opposing, hypsochromic and bathochromic shifts of the 1st UV–vis absorption bands.
David Dunlop, Rebecca Strada, Peter Šebej   +2 more
wiley   +1 more source

Comparison of Magnetostrictive-Actuated Semi-Active Control Methods Based on Synchronized Switching

Actuators
Three distinct synchronized switching circuits based on a magnetostrictive actuator are compared in this paper to examine their control mechanisms and circuit characteristics.
An Li, Yuusuke Kobayashi, Yushin Hara, Keisuke Otsuka, Kanjuro Makihara   +4 more
doaj   +1 more source

Improving the Thermostability of Serine Protease PB92 from Bacillus alcalophilus via Site-Directed Mutagenesis Based on Semi-Rational Design. [PDF]

Foods, 2023
Miao H, Xiang X, Han N, Wu Q, Huang Z.
europepmc   +1 more source

Conditions for Singular Incidence Matrices [PDF]

Suppose one looks for a square integral matrixN, for which NN has a prescribed form.Then the Hasse-Minkowski invariants and the determinant of NN lead to necessary conditions for existence.The Bruck-Ryser-Chowla theorem gives a famous example of such ...
Haemers, W.H.
core   +1 more source

From Strain to Pressure: Atomically Resolved Mechanisms of Stress Dissipation in Emissive, Elastically Deformable Molecular Crystals Under Ambient and High Pressure

Advanced Optical Materials, EarlyView.
Molecular crystals must withstand both isotropic and anisotropic stress to function in flexible optoelectronics and high‐pressure devices. In situ high‐pressure single‐crystal X‐ray diffraction coupled with DFT‐D computations reveal how an emissive molecular crystal with interdigitated packing bends elastically at ambient‐pressure and remains ...
Arif H. Dar, Vikram C. Joshi, Alexandra Longcake, Tamador Alkhidir, Ayat Al Nimer, Praveen B. Managutti, Shamraiz H. Talib, Jaime Viegas, Michael R. Probert, Changquan C. Sun, Sharmarke Mohamed   +10 more
wiley   +1 more source