Results 111 to 120 of about 372,053 (263)

Hard‐Magnetic Soft Millirobots in Underactuated Systems

Advanced Robotics Research, EarlyView.
This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang, Zixuan Zhang, Bingyan Li, Junkai Wang, Hongcheng Gu   +4 more
wiley   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Precise Engineering and Efficient Biosynthesis of Robust and High‐Activity Human Haemoglobin for Artificial Oxygen Carriers

Microbial Biotechnology
Recombinant human haemoglobin (rHb) is a tetramer protein with heme as cofactors, which have extensive applications in the fields of biomaterials and biomedical therapeutics.
Fan Liu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao   +5 more
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science
3‐Methyl‐1‐butanol (3‐MB), a promising next‐generation biofuel, has garnered significant interest owing to its superior combustion characteristics and fuel compatibility. However, current 3‐MB biosynthesis faces major challenges, including low production
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
doaj   +1 more source

Computational and experimental engineering of a Pleurotus citrinopileatus lipases: Structural insights and functional optimization to adapt the hydrolytic profile for cheese applications

Food Chemistry: X
Mutants of a golden oyster mushroom lipase (Pleurotus citrinopileatus; PCI_Lip), were engineered to enhance hydrolysis profiles for cheese production. Key residues affecting activity were identified by SMME (Structure model based on AlphaFold3 prediction,
Lea Henrich, Niklas Broel, Jonathan Schüler, Marius Lang, Binglin Li, Martin Gand   +5 more
doaj   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Tunnel Cross-section Optimization Design in Upper-soft Lower-hard Composite Strata Based on Lining Structure Minimum Bending Moment

Chengshi guidao jiaotong yanjiu
Objective To effectively prevent lining damage and water leakage in tunnels, research is carried out on minimizing lining structure bending moment for tunnel cross-section in upper-soft lower-hard composite strata.
ZHANG Huipeng, ZHANG Tao, SHI Yufeng, LAI Shihua, LIU Wei   +4 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Alloying and confinement effects on hierarchically nanoporous CuAu for efficient electrocatalytic semi-hydrogenation of terminal alkynes

Nature Communications
Electrocatalytic alkynes semi-hydrogenation to produce alkenes with high yield and Faradaic efficiency remains technically challenging because of kinetically favorable hydrogen evolution reaction and over-hydrogenation.
Linghu Meng, Cheng-Wei Kao, Zhen Wang, Jun Ma, Peifeng Huang, Nan Zhao, Xin Zheng, Ming Peng, Ying-Rui Lu, Yongwen Tan   +9 more
doaj   +1 more source