Results 41 to 50 of about 372,053 (263)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Engineering of isoamylase: improvement of protein stability and catalytic efficiency through semi-rational design

open access: yesJournal of Industrial Microbiology and Biotechnology, 2016
Abstract Isoamylase catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins. A semi-rational design strategy was performed to improve catalytic properties of isoamylase from Bacillus lentus. Three residues in vicinity of the essential residues, Arg505, Asn513, and Gly608, were chosen as the ...
Youran, Li   +4 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Enhancing the Activity and Thermostability of Glucose Oxidase Through Semi-rational Design

open access: yesShipin gongye ke-ji
This study aimed to simultaneously enhance the enzymatic activity and thermostability of glucose oxidase (AnGOD) derived from Aspergillus niger through a semi-rational design strategy.
Heyue LI   +8 more
doaj   +1 more source

Rationality, traditionalism and the state of corporate governance mechanisms: illustrations from a less developed country [PDF]

open access: yes, 2008
Purpose ? The purpose of this research is to provide an account of corporate governance practices in Bangladesh. This paper demonstrates that the traditionalist culture mediates the rationalist/legalist framework of corporate governance in Bangladesh ...
Choudhury, J, Uddin, S
core  

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Determining the potential of informal savings groups as a model for formal commitment saving devices

open access: yesSouth African Journal of Economic and Management Sciences, 2021
Background: Saving behaviour has attracted research attention over the past 20 years. Typically, individual and household saving rates among low-income groups are inadequate.
Marna Landman, Morris Mthombeni
doaj   +1 more source

Secure and Private Implementation of Dynamic Controllers Using Semi-Homomorphic Encryption [PDF]

open access: yes, 2019
This paper presents a secure and private implementation of linear time-invariant dynamic controllers using Paillier's encryption, a semi-homomorphic encryption method.
Farokhi, Farhad   +2 more
core   +2 more sources

From Single Atoms to Nanoparticles: Pathways Toward Efficient and Durable Pt/TiO2 Photocatalysts

open access: yesAdvanced Functional Materials, EarlyView.
Platinum single atoms on TiO2 nanosheets evolve into clusters and nanoparticles under ethanol photoreforming and thermal treatments. By controlling deposition and post‐treatments, particle size and location on specific facets are modulated. The study reveals how stability pathways determine efficiency, guiding the design of more durable photocatalysts.
Juan José Delgado   +6 more
wiley   +1 more source

SUBSTANTIATION OF A RATIONAL METHOD FOR DRYING WHEAT GLUTEN GRANULES IN A FLUIDIZED BED AND INSTALLATION FOR ITS IMPLEMENTATION

open access: yesСовременная наука и инновации, 2023
The object of research in the article is pre-frozen granules of gluten, which is produced from wheat grain and is used in the form of a powder in the food industry as an improver for the baking parameters of flour.
A. A. Pokoptseva   +4 more
doaj   +1 more source

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