Results 21 to 30 of about 372,053 (263)
Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design [PDF]
Current Issues in Molecular BiologyDermatan sulfate and chondroitin sulfate are dietary supplements that can be utilized as prophylactics against thrombus formation. Low-molecular-weight dermatan sulfate (LMWDS) is particularly advantageous due to its high absorbability.
Miao Tian +6 more
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A Whole-Cell Catalytic System for Equol Production Based on Daidzein Reductase Engineering [PDF]
MoleculesAs an isoflavone metabolite with diverse physiological activities, the development of efficient and sustainable manufacturing technologies for (S)-equol holds significant importance.
Bing-Juan Li +4 more
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Computational and Structural Biotechnology Journal, 2012 The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma +2 more
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Molecules, 2023 4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H; EC 1.14.14.9) is a heterodimeric flavin-dependent monooxygenase complex that catalyzes the ortho-hydroxylation of resveratrol to produce piceatannol.
Qianchao Zhang +8 more
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Semi-rational Design of Target-binding Small Proteins for Cancer Treatment
YAKUGAKU ZASSHI, 2020 Small proteins that have a high affinity for cancer cell surface markers can be promising cheap alternatives to antibodies (antibody mimetics). Various types of antibody mimetics have thus been extensively developed. We recently found that a target-binding peptide binds to its target molecule more strongly when it is structurally constrained.
T. Kadonosono, S. Kizaka-Kondoh
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Foods, 2022 In traditional cheese making, pregastric lipolytic enzymes of animal origin are used for the acceleration of ripening and the formation of spicy flavor compounds.
Niklas Broel +7 more
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Research Advances in Protein Engineering to Enhance the Thermal Stability of Glycosidase [PDF]
Shipin KexueGlycosidase is an indispensable enzyme in the sugar industry. It is difficult to maintain the stability of natural glycosidase during long-term high-temperature sugar conversion, limiting its application in industrial production.
WU Xiaoyi, WU Hao, YANG Can, WEN Shiyu, DUAN Yanting, TAN Wenzhi, XIE Yufei, CHENG Yunhui, WEN Li
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The Iterative Development of the Humanoid Robot Kaspar: An Assistive Robot for Children with Autism [PDF]
, 2017 This paper gives an overview of the design and development of the humanoid robot Kaspar. Since the first Kaspar robot was developed in 2005, the robotic platform has undergone continuous development driven by the needs of users and technological ...
Dautenhahn, Kerstin +5 more
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Semi‐Rationally Designed Short Peptides Self‐Assemble and Bind Hemin to Promote Cyclopropanation
Angewandte Chemie International Edition, 2020 AbstractThe self‐assembly of short peptides gives rise to versatile nanoassemblies capable of promoting efficient catalysis. We have semi‐rationally designed a series of seven‐residue peptides that form hemin‐binding catalytic amyloids to facilitate enantioselective cyclopropanation with efficiencies that rival those of engineered hemin proteins. These
Oleksii Zozulia, Ivan V. Korendovych
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Frontiers in Microbiology, 2022 Given the rapid development of genome mining in this decade, the substrate channel of paclitaxel might be identified in the near future. A robust microbial cell factory with gene dbat, encoding a key rate-limiting enzyme 10-deacetylbaccatin III-10-O ...
Jia-jun Huang +18 more
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