Results 141 to 150 of about 1,805,611 (181)
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Physiological and pathological implications of semicarbazide-sensitive amine oxidase
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of primary amines. Such deamination has been shown capable of regulating glucose transport in adipose cells. It has been independently discovered that the primary structure of vascular adhesion protein-1 (VAP-1) is identical to SSAO.
Peter H, Yu +4 more
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Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase
Journal of Histochemistry and Cytochemistry, 2001 SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines.
José M Lizcano +2 more
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Semicarbazide-sensitive amine oxidases in pig dental pulp
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003The behaviour of semicarbazide-sensitive amine oxidase (SSAO; E.C. 1.4.3.6) in dental pulp has been studied, with particular reference to the metabolism of 5-hydroxytryptamine (5-HT; serotonin). Kinetic studies using radioactively labelled substrates have confirmed benzylamine, 2-phenylethylamine (PEA) and 5-HT to be substrates for microsomal SSAO from
Michael, O'Sullivan +4 more
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Semicarbazide-sensitive amine oxidase (SSAO): present and future
InflammoPharmacology, 2003Although the existence of plasma and tissue-bound semicarbazide-sensitive amine oxidases (SSAOs) has been recognised for a long time, the physiological relevance of these enzymes still remains uncertain. The ability of SSAO to metabolise various aliphatic and aromatic monoamines differs between species, which limits the predictive value of the animal ...
Kálmán, Magyar, Zsuzsa, Mészáros
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Overexpression of semicarbazide‐sensitive amine oxidase in human myopathies
Muscle & Nerve, 2004AbstractOxidative stress has been implicated in the pathogenesis of several muscle diseases. Semicarbazide‐sensitive amine oxidase (SSAO) metabolizes oxidative deamination of primary aromatic and aliphatic amines. In the oxidative reactions, amine substrates are converted into the aldehyde, followed by the production of ammonia and H2O2.
Montse, Olivé +3 more
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Semicarbazide-Sensitive Amine Oxidase Activity in the Human Heart
Molecular Genetics and Metabolism, 1998A semicarbazide-sensitive amine oxidase with affinity for benzylamine (Bz.SSAO) was found in the human heart. This enzymatic activity has a K(m) of 278 +/- 35.3 microM and a V(m) of 114.7 +/- 14.7 nmol mg-1 min-1 (mean +/- SE of eight hearts) for benzylamine and is strongly inhibited by 1 mM histamine and by B24, a specific inhibitor of Bz.SSAO.
R, Pino, L, Mazzetti, F, Buffoni
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Semicarbazide-sensitive amine oxidase in pig heart
1998A semicarbazide-sensitive amine oxidase (SSAO) (E.C.1.4.3.6) has been purified from pig heart. Western blot analysis showed that the enzyme reacts with a polyclonal antibody raised against homogeneous crystalline pig plasma benzylamine oxidase (BAO). A subunit molecular mass of 97 KDa obtained by SDS electrophoresis is identical to the plasma enzyme ...
T G, Dowling, S, Cambi, F, Buffoni
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Semicarbazide-sensitive amine oxidase activity in catfish tissues
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19891. Semicarbazide-sensitive amine oxidase activity was found in five tissues of the siluroid catfish, Parasilurus asotus, using benzylamine as substrate. It was highest in the intestine, followed by the liver and skin. 2. The apparent Km value and optimal pH for benzylamine in the intestine were 49.8 microns and 8.8, respectively. 3.
T, Kumazawa, H, Seno, O, Suzuki
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Some aspects of the pharmacology of semicarbazide-sensitive amine oxidases
1990Semicarbazide-sensitive amine oxidase enzymes (SSAO) are found in animals, plants, fungi and bacteria. In vertebrates, their distribution in tissues and blood plasma varies between species. Studies of the SSAO enzymes have concentrated on their biochemical identities separate from those of MAO.
B A, Callingham, A, Holt, J, Elliott
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Semicarbazide-Sensitive Amine Oxidase (SSAO) in the Brain
Neurochemical Research, 2002Semicarbazide-sensitive amine oxidase (SSAO) is widely distributed in almost tissues. However, its presence in brain microvessels is still controversial. The affinity of SSAO towards benzylamine (Bz) is considerably higher than that of monoamine oxidase (MAO). SSAO plays a role in the toxicity of several environmental and endogenous amines.
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