Pharmacological and Structure-Activity Relationship Evaluation of 4-Aryl-1-Diphenylacetyl(Thio)Semicarbazides [PDF]
Molecules, 2014 This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Jolanta Orzelska-Górka +2 more
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New 4-(Morpholin-4-Yl)-3-Nitrobenzhydrazide Based Scaffold: Synthesis, Structural Insights, and Biological Evaluation [PDF]
MoleculesThe search for new antimicrobial agents is one of the major challenges in contemporary medicinal chemistry due to the global issue of increasing drug resistance.
Michał Janowski +8 more
doaj +3 more sources
Synthesis, Characterization, Anticancer, Antioxidant, and in Silico Evaluation of Semicarbazides and Thiosemicarbazides [PDF]
ACS OmegaAmara Mumtaz +2 more
exaly +3 more sources
Molecular Engineering of Binder for Improving the Mechanical Properties and Recyclability of Energetic Composites [PDF]
Nanomaterials, 2023 Mechanical properties and reprocessing properties are of great significance to the serviceability and recyclability of energetic composites. However, the mechanical robustness of mechanical properties and dynamic adaptability related to reprocessing ...
Jing Yang +6 more
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Strong and crack-tolerant elastomers via geometrically confined H-bonding semicarbazides [PDF]
Nature CommunicationsThe development of high-performance elastomers that are simultaneously strong, crack-tolerant, and wear-resistant remains a persistent challenge. Herein, we design bio-inspired semicarbazide chain extender featuring high-density hydrogen-bonding sites to
Rujuan Li +5 more
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Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives [PDF]
MoleculesCompounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds.
Paweł Kozyra +7 more
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Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties [PDF]
Saudi Pharmaceutical JournalIn order to obtain topical and non-irritating anti-glaucoma drugs, novel semicarbazide-containing sulfonamide derivatives were designed and synthetized by sugar tail method in this study.
Yingxia Xie +3 more
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Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators [PDF]
Molecules, 2022 Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu +7 more
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Ecotoxicology and Environmental Safety, 2023 Semicarbazide (SEM), the metabolite of antibiotic nitrofurazone, is often used as the biomarker to determine the use of nitrofurazone. Frequent false-positive events of SEM have brought great trouble to the aquatic industry in international trade.
Yi Zhang +5 more
doaj +1 more source
SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 1997 A series of 3(5)-substituted 1,2,4-triazole-5(3)-carboxylic acid amides, hydroxamic, hydrazide, iminosemicarbazide, semicarbazide and thiosemicarbazide have been synthesized. Most of the prepared compounds were tested for their growth inhibitory activity
A. Youssef +5 more
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