Molecules, 2014 This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Monika Wujec +2 more
exaly +4 more sources
New 4-(Morpholin-4-Yl)-3-Nitrobenzhydrazide Based Scaffold: Synthesis, Structural Insights, and Biological Evaluation [PDF]
MoleculesThe search for new antimicrobial agents is one of the major challenges in contemporary medicinal chemistry due to the global issue of increasing drug resistance.
Michał Janowski +8 more
doaj +3 more sources
Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides [PDF]
ACS OmegaSohail Anjum Shahzad +2 more
exaly +3 more sources
Molecular Engineering of Binder for Improving the Mechanical Properties and Recyclability of Energetic Composites [PDF]
Nanomaterials, 2023 Mechanical properties and reprocessing properties are of great significance to the serviceability and recyclability of energetic composites. However, the mechanical robustness of mechanical properties and dynamic adaptability related to reprocessing ...
Jing Yang +6 more
doaj +2 more sources
Solid-state Synthesis of 1-Ethoxycarbonyl-4-substituted-semicarbazides
Molecules, 2003 A rapid and simple method for the preparation of 1-ethoxycarbonyl-4-substituted-semicarbazides has been developed. As examples the reaction of six different isocyanates with ethyl carbazate under solvent-free conditions are reported.
Hedayat A. Taghizadeh +2 more
doaj +2 more sources
Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives [PDF]
MoleculesCompounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds.
Paweł Kozyra +7 more
doaj +2 more sources
Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties [PDF]
Saudi Pharmaceutical JournalIn order to obtain topical and non-irritating anti-glaucoma drugs, novel semicarbazide-containing sulfonamide derivatives were designed and synthetized by sugar tail method in this study.
Yingxia Xie +3 more
doaj +2 more sources
Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators [PDF]
Molecules, 2022 Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu +7 more
doaj +2 more sources
Molecules, 2015 This study addressed the design and syntheses of diverse ligands, which were then successfully treated with Ni (II) ion to afford a series of nickel complexes. α-Chloroformylarylhydrazine hydrochlorides 6 contain two different functional groups. One is
Mei-Hsiu Shih +3 more
doaj +2 more sources
Efficient Synthesis of Various Substituted (Thio)Ureas, Semicarbazides, Thiosemicarbazides, Thiazolidones, and Oxadiazole Derived from [2.2]Paracyclophane. [PDF]
ACS Omega, 2022 The strategies of the syntheses of various (thio)ureas, semicarbazides, thiosemicarbazides, thiazolidones, and oxadiazole derived from the [2.2]paracyclophane molecule are achieved starting with 4-(2.2]paracyclophanyl)isocyanate.
Alshammari MB +4 more
europepmc +2 more sources