Results 151 to 160 of about 2,006 (201)

Plasma Semicarbazide-Sensitive Amine Oxidase in Stroke

European Neurology, 1999
Semicarbazide-sensitive amine oxidase (SSAO) has been suggested to be involved in the development of vascular endothelial damage. The source of the soluble form of SSAO found in the blood serum is unknown. However, it has been speculated that it is secreted from cells within the vascular wall where high activity of the enzyme is found.
H, Garpenstrand, J, Ekblom, M, von Arbin, L, Oreland, V, Murray   +4 more
openaire   +2 more sources

Semicarbazide-sensitive amine oxidase and kidney disease

American Journal of Physiology-Renal Physiology, 2013
With better understanding of the molecular mechanisms underpinning chronic kidney disease, the roles of inflammation and fibrosis are becoming increasingly inseparable. The progression of renal disease is characterized by pathomorphological changes that consist of early inflammatory responses followed by tubulointerstitial fibrosis, tubular atrophy ...
May Y W, Wong, Sonia, Saad, Carol, Pollock, Muh Geot, Wong   +3 more
openaire   +2 more sources

The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Semicarbazide-sensitive amine oxidase (EC 1.4.3.6; amine:oxygen oxidoreductase (deaminating) (copper-containing); SSAO) is a multifunctional protein. It acts under inflammatory conditions as a vascular-adhesion protein (VAP-1), mediating the adhesion of lymphocytes to vascular endothelial cells. The relationships, if any, between this adhesion function
Jeffrey, O'Sullivan, Michael, O'Sullivan, Keith F, Tipton, Mercedes, Unzeta, Maria, Del Mar Hernandez, Gavin P, Davey   +5 more
openaire   +2 more sources

Semicarbazide-Sensitive Amine Oxidase: Current Status and Perspectives

Current Medicinal Chemistry, 2004
Semicarbazide-sensitive amine-oxidase (SSAO) is present in various human tissues and in plasma. Oxidative deamination of short-chain aliphatic amines is catalyzed by this enzyme to afford the corresponding aldehydes, ammonia and hydrogen peroxide. Methylamine and aminoacetone have been recognized to be physiological substrates for SSAO.
P. Mátyus, B. Dajka Halász, A. Földi, N. Haider, D. Barlocco, K. Magyar   +5 more
openaire   +3 more sources

Overexpression of semicarbazide‐sensitive amine oxidase in human myopathies

Muscle & Nerve, 2004
AbstractOxidative stress has been implicated in the pathogenesis of several muscle diseases. Semicarbazide‐sensitive amine oxidase (SSAO) metabolizes oxidative deamination of primary aromatic and aliphatic amines. In the oxidative reactions, amine substrates are converted into the aldehyde, followed by the production of ammonia and H2O2.
Montse, Olivé, Mercè, Unzeta, Dolores, Moreno, Isidro, Ferrer   +3 more
openaire   +2 more sources

Semicarbazide-sensitive amine oxidase in transgenic mice with diabetes

Biochemical and Biophysical Research Communications, 2004
Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds.
C, Gokturk, J, Nordquist, H, Sugimoto, K, Forsberg-Nilsson, J, Nilsson, L, Oreland   +5 more
openaire   +2 more sources

Semicarbazide-sensitive amine oxidase (SSAO): present and future

InflammoPharmacology, 2003
Although the existence of plasma and tissue-bound semicarbazide-sensitive amine oxidases (SSAOs) has been recognised for a long time, the physiological relevance of these enzymes still remains uncertain. The ability of SSAO to metabolise various aliphatic and aromatic monoamines differs between species, which limits the predictive value of the animal ...
Kálmán, Magyar, Zsuzsa, Mészáros
openaire   +2 more sources

Semicarbazide-sensitive amine oxidase activity in catfish tissues

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1989
1. Semicarbazide-sensitive amine oxidase activity was found in five tissues of the siluroid catfish, Parasilurus asotus, using benzylamine as substrate. It was highest in the intestine, followed by the liver and skin. 2. The apparent Km value and optimal pH for benzylamine in the intestine were 49.8 microns and 8.8, respectively. 3.
T, Kumazawa, H, Seno, O, Suzuki
openaire   +2 more sources

Semicarbazide-Sensitive Amine Oxidase Activity in the Human Heart

Molecular Genetics and Metabolism, 1998
A semicarbazide-sensitive amine oxidase with affinity for benzylamine (Bz.SSAO) was found in the human heart. This enzymatic activity has a K(m) of 278 +/- 35.3 microM and a V(m) of 114.7 +/- 14.7 nmol mg-1 min-1 (mean +/- SE of eight hearts) for benzylamine and is strongly inhibited by 1 mM histamine and by B24, a specific inhibitor of Bz.SSAO.
R, Pino, L, Mazzetti, F, Buffoni
openaire   +2 more sources

Physiological and pathological implications of semicarbazide-sensitive amine oxidase

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of primary amines. Such deamination has been shown capable of regulating glucose transport in adipose cells. It has been independently discovered that the primary structure of vascular adhesion protein-1 (VAP-1) is identical to SSAO.
Peter H, Yu, Shannon, Wright, Ellen H, Fan, Zhao-Rong, Lun, Diana, Gubisne-Harberle   +4 more
openaire   +2 more sources