Results 151 to 160 of about 1,805,611 (181)

Anti-Inflammatory Effects of Inhibiting the Amine Oxidase Activity of Semicarbazide-Sensitive Amine Oxidase

The Journal of Pharmacology and Experimental Therapeutics, 2005
Human semicarbazide-sensitive amine oxidase (SSAO) or vascular adhesion protein-1 (VAP-1) is a copper-containing amine oxidase (AOC3, EC 1.4.3.6) that has both enzymatic and adhesive function. SSAO catalyzes the oxidative deamination of primary amines, resulting in the formation of the corresponding aldehyde and release of hydrogen peroxide and ammonia.
Luisa M, Salter-Cid, Eric, Wang, Anne M, O'Rourke, Andrew, Miller, Hongfeng, Gao, Li, Huang, Arnie, Garcia, Matthew D, Linnik   +7 more
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Stereochemical course of tyramine oxidation by semicarbazide-sensitive amine oxidase

Biochemistry, 1992
Two semicarbazide-sensitive amine oxidases (SSAO's) from bovine and porcine aortic tissue were partially purified and characterized, and the stereochemical course of amine oxidation was evaluated. The porcine and bovine SSAO's were membrane bound glycoproteins, with Km values for benzylamine of 8 and 16 microM, respectively. The reactivity of SSAO with
C H, Scaman, M M, Palcic
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Hypoxia inhibits semicarbazide-sensitive amine oxidase activity in adipocytes

Molecular and Cellular Endocrinology, 2015
Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity.
Repessé, Xavier, Moldes, Marthe, Muscat, Adeline, Vatier, Camille, Chetrite, Gérard, Gille, Thomas, Planès, Carole, Filip, Anna, Mercier, Nathalie, Duranteau, Jacques, Fève, Bruno   +10 more
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Aminoacetone metabolism by semicarbazide-sensitive amine oxidase in rat aorta

Biochemical Pharmacology, 1995
High speed (105,000 g/60 min) membrane fractions from rat aorta homogenates metabolized the aliphatic amine aminoacetone (AA) to methylglyoxal (MG) with a Km of 19 +/- 3 microM, and Vmax of 510 +/- 169 nmol MG/hr/mg protein. This deaminating activity appears to be due to a semicarbazide-sensitive amine oxidase (SSAO), which is associated with smooth ...
G A, Lyles, J, Chalmers
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Plasma semicarbazide-sensitive amine oxidase in human (patho)physiology

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Semicarbazide-sensitive amine oxidases (SSAO) are widely distributed enzymes, with as yet not fully elucidated functions and roles, present in many tissues but also circulating in plasma. The enzyme also functions as an adhesion molecule, the vascular adhesion protein-1.
Boomsma, Frans, Bhaggoe, V, Houwen, Angelique, van den Meiracker, Ton   +3 more
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Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye

1990
The activities of MAO-A, MAO-B and the semicarbazide-sensitive amine oxidase (SSAO) were determined in bovine lens, retina, optic nerve, iris and epithelium. No activities were detected in lens but the SSAO activity was found to be rather evenly distributed in the other tissues.
A, Fernandez de Arriba, D, Balsa, K F, Tipton, M, Unzeta   +3 more
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Semicarbazide-sensitive amine oxidase kills African trypanosomes in vitro

Acta Tropica, 2011
The African trypanosome Trypanosoma brucei is the cause of sleeping sickness in humans and Nagana in animals. Here we report that semicarbazide-sensitive amine oxidases (SSAOs), enzymes that are abound in T. brucei mammal hosts, eliminate trypanosomes by oxidation of its substrate in vitro. SSAO and its endogenous substrate methylamine are not toxic to
Qiao-Ping, Wang, De-Hua, Lai, Zhi, Li, Feng-Jun, Li, Zhao-Rong, Lun   +4 more
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CULTURE MEDIUM ENHANCES SEMICARBAZIDE-SENSITIVE AMINE OXIDASE ACTIVITY

In Vitro Cellular & Developmental Biology - Animal, 2002
Components of fetal calf serum (FCS) are known to contribute to growth and maintenance of cultured cells. Fetal calf serum supplementation of media also may contribute to the cytotoxicity of other substances to cells grown in vitro. Semicarbazide-sensitive amine oxidase (SSAO) enzyme, present in FCS, metabolizes primary amines and contributes to amine ...
M B, Trent, D J, Conklin, P J, Boor
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Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do

NeuroToxicology, 2004
The semicarbazide-sensitive amine oxidases (SSAO) (EC 1.4.3.6) were believed to be detoxifying enzymes, primarily involved in the oxidative deamination of endogenous amines, such as methylamine and aminoacetone, together with some xenobiotic amines. However, it appears that the reaction products may have important signalling functions in the regulation
Jeff, O'Sullivan, Mercedes, Unzeta, Joe, Healy, Michael I, O'Sullivan, Gavin, Davey, Keith F, Tipton   +5 more
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Inhibition of bovine plasma semicarbazide‐sensitive amine oxidase by caffeine

Journal of Biochemical and Molecular Toxicology, 2011
AbstractSemicarbazide‐sensitive amine oxidase (SSAO) is a copper‐containing enzyme that catalyzes the oxidative deamination of endogenous and exogenous primary amines. SSAO exists in mammals both as a plasma‐soluble and as a membrane‐bound form, and its active site is able to come into contact with numerous xenobiotic, amine‐containing compounds.
A, Olivieri, K, Tipton
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