Results 41 to 50 of about 5,696,429 (330)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Direct images of semi-meromorphic currents [PDF]

Annales de l'Institut Fourier, 2018
We introduce a calculus for the class ASM(X) of direct images of semi-meromorphic currents on a reduded analytic space X, that extends the classical calculus due to Coleff, Herrera and Passare. Our main result is that each element in this class acts as a kind of multiplication on the sheaf 𝒫ℳ X of pseudomeromorphic currents on X.
Andersson, Mats, Wulcan, Elizabeth
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effets des systèmes en semis direct sur l'érosion hydrique et les rendements des cultures pluviales sur les Hautes Terres centrales malgaches [PDF]

, 2015
Deux pratiques culturales, (i) semis direct sous couverture morte de résidus des cultures antérieures (SDm) et (ii) labour sans restitution des résidus des cultures (LABe), sont comparées, depuis six ans, dans un dispositif expérimental de mesure de l ...
Andriamaniraka, Harilala, Douzet, Jean-Marie, Rakotoalibera, Mamy Haingotiana, Razafindramananana, Norosoa Christine, Remamy, Razafimiroe Randzavola Nirina   +4 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effet à moyen et à long terme du Semis direct sur la matière organique, la stabilité structurale et la compaction des sols argileux au Maroc

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2019
Au Maroc, les effets des changements climatiques couplés à la dégradation des ressources en sol constituent des facteurs majeurs limitant le développement socio-économique.
Malika LAGHROUR, Rachid MOUSSADEK, Rachid MRABET, Mohammed MEKKAOUI   +3 more
doaj  

Direction-Aware Semi-Dense SLAM

, 2017
To aide simultaneous localization and mapping (SLAM), future perception systems will incorporate forms of scene understanding. In a step towards fully integrated probabilistic geometric scene understanding, localization and mapping we propose the first direction-aware semi-dense SLAM system.
Straub, Julian, Cabezas, Randi, Leonard, John, Fisher III, John W.   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Le paillage du sol. Une alternative techniquement simple [PDF]

, 2002
Le système techniquement le plus simple consiste à un semis direct dans un paillage constitué des mauvaises herbes et/ou de mulch importé. Malgré une restauration plus modérée de la fertilité du sol, il permet de découvrir facilement le semis direct tout
Chabanne, André, Ha Dinh Tuan,, Husson, Olivier, Lienhard, Pascal, Séguy, Lucien   +4 more
core