Results 11 to 20 of about 8,472,955 (236)
Journal of Orthopaedic TranslationAs a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu +3 more
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Antioxidants, 2023 Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou +6 more
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CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos [PDF]
, 2022 Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women.
KAWAMURA, Kazuhiro +5 more
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Senescent cells and macrophages: key players for regeneration? [PDF]
Open Biology, 2020 Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
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Molecular Oncology, 2021 Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers +3 more
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Senescence: Definition, mechanisms of occurence and detection in tissues [PDF]
Medicinski PodmladakA cellular senescence represents a state, which is defined as a stable blockage of the cellular cycle in the G1 phase, as an answer to multiple triggers and their qualitative and quantitative characteristics. Alongside the blockage of the cellular cycle,
Mijajlović Vladimir +2 more
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The Paradoxical Role of Cellular Senescence in Cancer
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang +7 more
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HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]
, 2016 The senescence - associated secretory phenotype (SASP) is a hallmark of senescence with important physiological impact, but how it is established is unclear . In this issue , Aird and colleagues ( 2016. J Cell Biol.
guerrero a, Gil, J
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Radiation-induced senescence: therapeutic opportunities
Radiation Oncology, 2023 The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim +2 more
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G3BP1 controls the senescence-associated secretome and its impact on cancer progression
Nature Communications, 2020 The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer +6 more
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