Results 31 to 40 of about 31,992 (113)
Giant Multinucleated Cells in Aging and Senescence—An Abridgement
Biology, 2022 This review introduces the subject of senescence, aging, and the formation of senescent multinucleated giant cells. We define senescence and aging and describe how molecular and cellular senescence leads to organismal senescence.
Malgorzata Kloc +5 more
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Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases
JACC: Basic to Translational ScienceSummary: The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a senescence-associated secretory phenotype, which has ...
Manish Kumar, MD +3 more
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Brief guide to senescence assays using cultured mammalian cells
Molecules and Cells: Cellular senescence is a crucial biological process associated with organismal aging and many chronic diseases. Here, we present a brief guide to mammalian senescence assays, including the measurement of cell cycle arrest, change in cellular morphology,
Eunseok Kang +3 more
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The Regulation of Cellular Senescence in Cancer
BiomoleculesCellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang +6 more
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Dissecting Aging and Senescence—Current Concepts and Open Lessons
Cells, 2019 In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of ...
Christian Schmeer +4 more
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Cellular senescence in cancer: molecular mechanisms and therapeutic targets
MedCommAging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin +5 more
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Expression of Senescence-Associated Secretory Phenotype in Senescent Gingival Fibroblasts
치위생과학회지, 2023 Background: Although microbial infection is direct cause of periodontal disease, various environmental factors influence the disease severity. Aging is considered a risk factor for oral diseases, with the prevalence of periodontal diseases increasing ...
Sangim Lee
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Türk Biyokimya DergisiChemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber +4 more
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PathogensRecently, we reported that oral-epithelial cells (OE) are unique in their response to Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis.
Bruce J. Shenker +6 more
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Inflammasome activation and accelerated immune aging in autoimmune disorders
Frontiers in AgingAutoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are paradoxically characterized by molecular and cellular features typically associated with aging.
Rahul Mittal +7 more
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