Results 21 to 30 of about 31,992 (113)

QS2: Aberrant Breast Adipose Stromal Cell Biology In Women At High Risk For Developing Breast Cancer

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: Our laboratory studies contributions of breast adipose stromal cells (bASCs) to breast cancer initiation and progression. To date, most studies of ASC biology have focused on abdominal ASCs.
Mahsa Taskindoust, BS, Tingjun Xie, MD, Valery Nelson, MS, Bryanna Stukes, MHS, Scott Hollenbeck, MD, Robin Bachelder, PhD   +5 more
doaj   +1 more source

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +1 more source

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix   +2 more
doaj   +1 more source

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
doaj   +1 more source

Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

Journal of Ovarian Research, 2022
Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells.
Szymon Rutecki, Paulina Szulc, Martyna Pakuła, Paweł Uruski, Artur Radziemski, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +9 more
doaj   +1 more source

A Model for p38MAPK-Induced Astrocyte Senescence.

PLoS ONE, 2015
Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach, Bruno Vendrusculo, Cristhian A Bugs   +2 more
doaj   +1 more source

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

Cells
Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz   +3 more
doaj   +1 more source

TP53 mutation‐related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles

Smart Medicine, 2023
TP53 mutation frequently occurs in hepatocellular carcinoma (HCC). Senescence also plays a vital role in the ongoing process of HCC. P53 is believed to regulate the advancement of senescence in HCC.
Yu‐Yan Chen, Zheng‐Yi Zhu, Tao Ma, Lu Zhang, Jing Chen, Jia‐Wei Jiang, Cui‐Hua Lu, Yi‐Tao Ding, Wen‐Xian Guan, Nan Yi, Hao‐Zhen Ren   +10 more
doaj   +1 more source

Elevated senescence-associated secretory phenotype index in late-life bipolar disorder [PDF]

Journal of Affective Disorders
Tessema T, Diniz BS, Vieira EM, Mendes-Silva AP, Voineskos AN, Gildengers AG, Husain MI, Ortiz A, Blumberger DM, Rajji TK, Mulsant BH.   +10 more
exaly   +2 more sources

Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Neoplasia: An International Journal for Oncology Research, 2011
Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.
Zuzana Pernicová, Eva Slabáková, Gvantsa Kharaishvili, Jan Bouchal, Milan Král, Zuzana Kunická, Miroslav Machala, Alois Kozubík, Karel Součcek   +8 more
doaj   +1 more source