Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype. [PDF]
, 2015 OBJECTIVE: Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process.
Sarah E. Gardner +3 more
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Targeting the senescence-associated secretory phenotype in cancer therapy
, 2023 The current main strategy in the treatment of cancer is to target rapidly dividing cells, which induces DNA damage and promotes senescence in both cancerous and non-malignant cells alike.
Niamh Kerslake (16845207)
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Redox control of senescence and age-related disease
Redox Biology, 2017 The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran +2 more
doaj +1 more source
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
Physiological Reports, 2020 Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion +7 more
doaj +1 more source
Identification and study of a role for toll-like receptors in oncogene-induced senescence
, 2018 Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising of the activation of tumour ...
Hari, Priya
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Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype
, 2020 Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging.
Peter F. Doubleday (8364153) +2 more
core +4 more sources
The Senescence-Associated Secretory Phenotype Promotes Benign Prostatic Hyperplasia [PDF]
, 2014 Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone of the prostate, which leads to obstruction of urine outflow and considerable morbidity in a majority of older men.
Vital, Paz +3 more
core +1 more source
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy
Frontiers in Oncology, 2018 In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh +9 more
doaj +1 more source
Cellular & Molecular Biology Letters, 2021 Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management.
Paweł Uruski +8 more
doaj +1 more source
Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
PharmaceuticalsAging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier +2 more
doaj +1 more source