Results 81 to 90 of about 1,180 (262)
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Revista Árvore, 2015 Mesmo adaptadas à baixa fertilidade dos solos, acredita-se que as espécies de plantas do Cerrado seriam capazes de responder a uma maior disponibilidade de nutrientes e alterar sua produtividade.
Klécia Gili Massi
doaj +1 more source
Assessment of Peripheral Blood Mononuclear Cells Senescence and Endothelial Dysfunction among Adults with High Cardiovascular Risk. [PDF]
Arq Bras Cardiol, 2021 Raj V +8 more
europepmc +1 more source
Papel homeostático e inflamatorio de neutrófilos senescentes [PDF]
, 2017 Los neutrófilos son los leucocitos más abundantes en la circulación humana y representan la primera barrera de defensa contra microorganismos patógenos. Su número en circulación muestra un comportamiento temporalmente oscilatorio, con una periodicidad circadiana.
openaire +1 more source
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Cuidado formal em saúde bucal: percepção de senescentes [PDF]
, 2012 Ações promotoras de saúde e independência para pessoas idosas são indispensáveis. Compreender essa construção no cotidiano da provisão dos cuidados talvez estimule o desenvolvimento de capacitações ao bem estar nesta população.
Oliveira, Maria de Fátima Jorge de
core
Evolution and structure of Artikutza, an 80-year-old beech forest in navarra (northern Spain) [PDF]
Munibe Ciencias Naturales, 2009 Se ha estudiado la estructura forestal y la historia del hayedo de Artikutza. El objetivo ha sido analizar la evolución natural y recuperación del bosque tras 80 años sin intervenciones significativas.
Castro Gil, A.
doaj
[Geroscience in times of global pandemic by COVID-19]. [PDF]
Rev Esp Geriatr Gerontol, 2021 Castro-Fuentes R +2 more
europepmc +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source