Results 11 to 20 of about 63,937 (247)

The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives

open access: yesBrain and Behavior, 2023
The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients.
Rikuya Yoshimura   +6 more
doaj   +1 more source

Aluminum chloride impaired spatial memory, but not senile plaques formation in the rat model of Alzheimer’s disease

open access: yesSains Medika, 2022
Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD).
Muhammad Ihwan Narwanto   +3 more
doaj   +1 more source

Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. [PDF]

open access: yesPLoS ONE, 2012
Beta amyloid (Aβ) deposits are seen in aged individuals in many of the mammalian species that possess the same Aβ amino acid sequence as humans. Conversely, neurofibrillary tangles (NFT), the other hallmark lesion of Alzheimer's disease (AD), are ...
James K Chambers   +9 more
doaj   +1 more source

Microbial involvement in Alzheimer disease development and progression

open access: yesMolecular Neurodegeneration, 2020
Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors.
Hannah R. Bulgart   +3 more
doaj   +1 more source

Aβ plaques

open access: yesFree Neuropathology, 2020
Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer’s disease. Plaques are highly diverse structures; many of them include massed, fibrillar polymers of the Aβ protein referred to as Aβ-amyloid, but
Lary C Walker
doaj   +1 more source

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

open access: yes, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S.   +3 more
core   +1 more source

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