Results 11 to 20 of about 365,500 (282)

Enrichment of cholesterol in microdissected Alzheimer’s disease senile plaques as assessed by mass spectrometry

Journal of Lipid Research, 2010
Extensive knowledge of the protein components of the senile plaques, one of the hallmark lesions of Alzheimer’s disease, has been acquired over the years, but their lipid composition remains poorly known. Evidence suggests that cholesterol contributes to
Maï Panchal, Jacqueline Loeper, Jack-Christophe Cossec, Claire Perruchini, Adina Lazar, Denis Pompon, Charles Duyckaerts   +6 more
doaj   +2 more sources

Aβ plaques

Free Neuropathology, 2020
Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer’s disease. Plaques are highly diverse structures; many of them include massed, fibrillar polymers of the Aβ protein referred to as Aβ-amyloid, but
Lary C Walker
doaj   +2 more sources

Aluminum chloride impaired spatial memory, but not senile plaques formation in the rat model of Alzheimer’s disease [PDF]

Sains Medika, 2022
Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD).
Muhammad Ihwan Narwanto, Masruroh Rahayu, Setyawati Soeharto, Nurdiana Nurdiana   +3 more
doaj   +2 more sources

The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques. [PDF]

Biochemistry, 2013
Copper coexists with amyloid-β (Aβ) peptides at a high concentration in the senile plaques of Alzheimer's disease (AD) patients and has been linked to oxidative damage associated with AD pathology.
D. Jiang, Lin Zhang, G. P. Grant, Christopher G. Dudzik, Shu Chen, S. Patel, Yuanqiang Hao, G. Millhauser, F. Zhou   +8 more
semanticscholar   +2 more sources

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric [PDF]

, 2002
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very
Broeckhoven, C. (Christine) van, Ceuterick, C., Cras, P. (Patrick), Duijn, C.M. (Cornelia) van, Kros, J.M. (Johan), Kumar-Singh, S. (Samir), Lubke, U., Marck, E.A. (Eric) van, Martin, J-J. (Jean-Jacques), Serneels, S. (Sally), Swieten, J.C. (John) van, Timmermans, J.P., Vennekens, K., Wang, R. (Rong)   +13 more
core   +3 more sources

Senile Plaques in an Aged Western Lowland Gorilla.

Experimental Animals, 2001
Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red.
Nobuyuki Kimura, Itsuko Hara, Etsuo Narushima, Seiji Kawamura, Shinichiro Nakamura, Masao Nose, Yasuhiro Yoshikawa, Takako Hayashi, Shigemi Shichiri, Naoaki Goto, Kazuo Saitou   +10 more
openaire   +5 more sources

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease [PDF]

Journal of Neuropathology and Experimental Neurology, 2012
A. Hoshi, Teiji Yamamoto, K. Shimizu, Y. Ugawa, M. Nishizawa, H. Takahashi, A. Kakita   +6 more
semanticscholar   +2 more sources

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2009
Robert M. Koffie, Melanie Meyer-Luehmann, T. Hashimoto, Kenneth W Adams, Matthew L Mielke, M. Garcia-Alloza, Kristina D. Micheva, Stephen J. Smith, M. L. Kim, V. Lee, B. Hyman, T. Spires-Jones   +11 more
semanticscholar   +2 more sources

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

Proceedings of the National Academy of Sciences of the United States of America, 1995
Bradley T. Hyman, H. West, G. Rebeck, S. Buldyrev, R. Mantegna, M. Ukleja, S. Havlin, H. Stanley   +7 more
semanticscholar   +2 more sources

Origins of the Superiority of Oscillating Electric Fields for Disrupting Senile Plaques: Insights from the 7-Residue Fragment and the Full-length Aβ-42 Peptide. [PDF]

J Am Chem Soc
Kalita S, Danovich D, Shaik S.
europepmc   +2 more sources