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Senile plaques in temporal lobe epilepsy
Acta Neuropathologica, 1994Senile plaques (SP) are one of the characteristic pathological lesions of Alzheimer's disease (AD). They are also seen in the brains of some non-demented individuals as an age-related change. Identification of clinical conditions associated with these "incidental" SP could provide insight into AD pathogenesis.
I R, Mackenzie, L A, Miller
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Senile plaques in very aged cats
Acta Neuropathologica, 1996Senile plaques were found in the cerebral cortices of three very aged cats (more than 18 years old). The plaques consisted of a coarse assembly of silver staining-positive materials, and was morphologically different from the well-known classical, primitive, and diffuse plaques.
S, Nakamura +5 more
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Molecular interactions of acetylcholinesterase with senile plaques
Journal of Physiology-Paris, 1998Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these ...
N C, Inestrosa, R, Alarcón
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Evidence for Cholinergic Neurites in Senile Plaques
Science, 1984In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course.
C A, Kitt +6 more
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Role of microglia in senile plaque formation
Neurobiology of Aging, 1995To assess the role of microglial cells in senile plaque (SP) formation, we examined the density and distribution of microglia in the temporal neocortex of three groups of nondemented individuals, chosen to represent sequential stages of SP formation (no SP, n = 14; diffuse plaques (DP) only, n = 12; both DP and neuritic plaques (NP), n = 14) and ...
I R, Mackenzie, C, Hao, D G, Munoz
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SENILE PLAQUES AND TANGLES IN DIALYSIS DEMENTIA
Acta Pathologica Microbiologica Scandinavica Section A Pathology, 1981The brains of 7 patients, treated with hemodialysis were studied. Four of these patients had the dialysis encephalopathy syndrome (DES). Senile plaques and or neurofibrillary tangles were found in 5 of the 7 cases, 3 with and 2 without DES. One case of each group had plaques to an extent compatible with that in Alzheimer's disease, though of a ...
A, Brun, M, Dictor
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Archives of Neurology And Psychiatry, 1936
In spite of a great deal of study, both histopathologic and histochemical, no agreement has been reached as to the exact origin of the characteristic plaques that occur in the brain in cases of senile dementia. A survey of the extensive literature indicates that the hypotheses concerning the histogenesis of these senile plaques may be briefly listed as
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In spite of a great deal of study, both histopathologic and histochemical, no agreement has been reached as to the exact origin of the characteristic plaques that occur in the brain in cases of senile dementia. A survey of the extensive literature indicates that the hypotheses concerning the histogenesis of these senile plaques may be briefly listed as
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Senile plaques as aberrant sprout-stimulating structures
Experimental Neurology, 1986In Alzheimer's disease, the cholinergic septal input to the dentate gyrus molecular layer appears to sprout, presumably in response to the loss of entorhinal input to this region. Neuritic plaques accumulated in regions of septal sprouting and were present in these regions to a much greater degree than in areas of no apparent sprouting. We suggest that
J W, Geddes, K J, Anderson, C W, Cotman
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Microanalysis of Senile Plaques Using Nuclear Microscopy
Journal of Geriatric Psychiatry and Neurology, 1993Silver-staining “senile” plaques occurring in the brain are a major part of the pathology of Alzheimer's disease. The elemental composition of these structures, and the possible presence of aluminum and silicon in these structures, has been the subject of an increasing research effort over the last decade.
J, Landsberg +3 more
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HISTOGENESIS OF SENILE PLAQUES
Archives of Neurology And Psychiatry, 1941The first reference in the literature to the existence of senile plaques was made as early as 1892,1but the origin and development of such plaques are still a matter of controversy. No less than twenty different concepts regarding their origin have appeared in the literature.
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