Comparative LC-ESIMS-Based Metabolite Profiling of Senna italica with Senna alexandrina and Evaluating Their Hepatotoxicity [PDF]
Metabolites, 2023 Senna Mill. (Fabaceae) is an important medicinal plant distributed worldwide. Senna alexandrina (S. alexandrina), the officinal species of the genus, is one of the most well-known herbal medicines traditionally used to treat constipation and digestive ...
Elaheh Zibaee +7 more
doaj +2 more sources
Journal of the Anus, Rectum and Colon, 2021 Objectives: To evaluate 20 Kampo medicines, which comprised 6 formulas, Otsujito, Junchoto, Tokakujokito, Bofutsushosan, Mashiningan, and Keishikashakuyakudaioto, from 7 brands, to create a ranking of Kampo medicines for appropriate selection of ...
Kakuyou Ogawa
exaly +3 more sources
Determination of Total Sennosides and Sennosides A, B, and A1 in Senna Leaflets, Pods, and Tablets by Two-Dimensional qNMR [PDF]
Molecules, 2022 In the present work, a two-dimensional qNMR method for the determination of sennosides was established. Using band-selective HSQC and the cross correlations of the characteristic 10–10’ bonds, we quantified the total amount of the value-determining ...
Serhat Sezai Çiçek +2 more
doaj +2 more sources
Determination of 16 Hydroxyanthracene Derivatives in Food Supplements Using LC-MS/MS: Method Development and Application [PDF]
ToxinsHydroxyanthracene derivatives (HADs) are plant substances produced by a variety of plant species, including different Aloe, Rheum, and Rhamnus species and Cassia senna. These plants are often used in food supplements to improve bowel function.
Svetlana V. Malysheva +3 more
doaj +2 more sources
Physiological and Metabolic Effects of Opuntia ficus indica spp. Peel Formulations [PDF]
LifeThe objective of this study is to determine the physiological and metabolic effects of administration of dietary fiber formulations to male Wistar rats. The study population was divided into five groups to which food and water were orally administered ad
José Arias-Rico +7 more
doaj +2 more sources
Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats [PDF]
International Journal of Molecular Sciences, 2018 Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific justification. In this study, senna extract (SE), sennosides (SS), and sennoside A (SA) were prepared and
Ying Cheng, Dandan Wang, Boling Qiao
exaly +3 more sources
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryThe nucleocapsid protein (NP) of SARS-CoV-2, an RNA-binding protein, is capable of undergoing liquid-liquid phase separation (LLPS) during viral infection, which plays a crucial role in virus assembly, replication, and immune regulation.
Da-Wei Zhang +6 more
doaj +2 more sources
Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts) [PDF]
Frontiers in Cellular and Infection MicrobiologyThe genus Senna contains globally distributed plant species of which the leaves, roots, and seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds derived from Senna spp.
Adrienne B. Narrowe +9 more
doaj +2 more sources
Metabolomics analysis reveals the metabolite profiles of Rheum tanguticum grown under different altitudinal gradients [PDF]
BMC Plant BiologyBackground Plant growth and quality are often affected by environmental factors, including geographical location, climate, and soil. In this study, we describe the effect of altitudinal differences on the growth and active ingredients in Rheum tanguticum
Lingling Wang +3 more
doaj +2 more sources
Annals of Medicine, 2021 Background To the best of our knowledge, the effectiveness and safety of lactulose in comparison to sennosides, for the prevention of peritoneal dialysis (PD)-related peritonitis, has never been tested in a randomized study.Methods We conducted an open ...
Kajohnsak Noppakun +6 more
doaj +1 more source