Photostability of sennosides in solution and their degradation products 1 [PDF]
, 2017 The leaves and pods of Alexandrian and Tinnevelly senna were used for centuries as laxatives. Their main active constituents are the dianthron glucosides (sennoside A – D and A1) and anthraquinone glucosides [1].
Josic, Goijko +9 more
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Acceleration of large intestine transit time in rats by sennosides and related compounds [PDF]
, 1986 Sennosides A + B and their natural metabolites, sennidins A + B, rheinanthrone and rhein, as well as the synthetic laxative danthron, were investigated for their influence on small and large intestine transit time in rats.
Elke Leng-Peschlow
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Acta Pediátrica de México, 2014 Introduction: in Mexico, approximately 1 000 children each year are born with anorectal malformation (ARM). Despite surgical correction, those children present fecal function problems (60-70% have difficult to manage constipation).
Karla A. Santos Jasso +4 more
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HPTLC fingerprint method for the detection of sennosides in Senna dry extracts [PDF]
, 2017 In 2015 a new HPTLC method was proposed as part of the revision of the herbal drug monographs in the European Pharmacopeia Ph.Eur. of senna leafs and pods [1].
E Wolfram +7 more
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Compounded laxative formulations for substituting phenolphthalein with sennosides A & B in solid dosage forms [PDF]
, 2004 Purpose: Following the discovery of the carcinogenicity of phenolphthalein and the subsequent ban of this compound in several countries this study was undertaken to develop compounded formulations of laxative products containing the stimulant ...
Melgardt M. de Villiers +4 more
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Determination of Sennoside A and Sennoside B in Formulation Using Capillary Electrophoresis
YAKUGAKU ZASSHI, 1999 The determination of sennoside A (SA) and sennoside B (SB) by capillary zone electrophoresis was developed. The separation of SA and SB was performed in 100 mM of the 3-[cyclohexylamino]-1-propanesulfonic acid (CAPS) buffer (pH 10.0), and the migration time of SA and SB was found to be both less than 7 min.
K, Satoh +5 more
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Secretagogue laxatives as a potential strategy to overcome adherence barriers to over-the-counter treatment for clozapine-induced constipation [PDF]
Mental Health ClinicianIntroduction Clozapine-induced constipation may occur in at least 60% of patients, with first-line options typically involving polyethylene glycol or sennosides.
Jonathan G. Leung, PharmD +2 more
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Pharmacokinetics of Anthraquinones from Medicinal Plants
Frontiers in Pharmacology, 2021 Anthraquinones are bioactive natural products, some of which are active components in medicinal medicines, especially Chinese medicines. These compounds exert actions including purgation, anti-inflammation, immunoregulation, antihyperlipidemia, and ...
Dongpeng Wang +13 more
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Docusate and Sennosides for Constipation (DRAFT) [PDF]
, 2018 This chapter describes a prospective study that ran from December 2005 to November 2010 using three hospital inpatient units of adding a stool softener, docusate versus placebo, to sennosides alone for the treatment of constipation among hospice patients.
Shalini Dalal
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Protective mechanism on gastric lesion of Sennoside A and Sennoside B
The FASEB Journal, 2015 Sennoside A and sennoside B is evacuant to increase the sensitivity of the colon. In vivo test, we performed HCl·ethanol‐induced gastritis test, indomethacin‐induced gastric ulcer test, gastric secretion in pylorus‐ligated test, H + /K
In Young Hwang +6 more
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