Results 81 to 90 of about 236,488 (384)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Unveiling the pivotal influence of sea spray heat fluxes on hurricane rapid intensification

Environmental Research Letters
Predicting rapid hurricane intensification remains a challenge, partially due to neglected factors like sea spray-mediated heat flux. To shed light on the specific roles of spray-mediated sensible and latent heat fluxes, we conducted sensitivity ...
Sinil Yang, DW Shin, Steven Cocke, Chaehyeon Chelsea Nam, Mark Bourassa, Dong-Hyun Cha, Baek-Min Kim   +6 more
doaj   +1 more source

Sensible heat flux records constrain projections of European warming [PDF]

Eos, Transactions American Geophysical Union, 2013
Rising atmospheric concentrations of greenhouse gases are adding more energy to the Earth system, but how that extra energy turns to heat—and where that heating takes place—depends in part on regional variations in how the atmosphere and the land surface interact.
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Using sonic anemometer temperature to measure sensible heat flux in strong winds

, 2012
. Sonic anemometers simultaneously measure the turbulent fluctuations of vertical wind (w') and sonic temperature (Ts'), and are commonly used to measure sensible heat flux (H).
S. Burns, T. W. Horst, L. Jacobsen, P. Blanken, R. Monson   +4 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Upscaling surface energy fluxes over the North Slope of Alaska using airborne eddy-covariance measurements and environmental response functions [PDF]

Atmospheric Chemistry and Physics, 2018
The objective of this study was to upscale airborne flux measurements of sensible heat and latent heat and to develop high-resolution flux maps. In order to support the evaluation of coupled atmospheric–land-surface models we investigated spatial ...
A. Serafimovich, S. Metzger, S. Metzger, J. Hartmann, K. Kohnert, D. Zona, D. Zona, T. Sachs, T. Sachs   +8 more
doaj   +1 more source

Modelling the partitioning of turbulent fluxes at urban sites with varying vegetation cover [PDF]

, 2016
Inclusion of vegetation is critical for urban land surface models (ULSM) to represent reasonably the turbulent sensible and latent heat flux densities in an urban environment.
Best, M. J., Grimmond, C. S. B.
core   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source