Results 101 to 110 of about 2,191,303 (292)

Summer soil moisture-convective precipitation coupling in Northern China at different timescales

Journal of Hydrology: Regional Studies
Land-atmosphere coupling plays an important role in regional precipitation and climate change, but the coupling characteristics at different time scales remain controversial.
Hongwei Yang, Zesu Yang, Hang He
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Turbulent sensible heat flux in complex terrain

, 2023
Turbulent sensible heat flux is a measure of heat transfer between the surface and the atmosphere. In stably stratified conditions, such as found during night-time and over the glaciers, the sensible heat flux is warming the surface since the heat is transferred from the atmosphere towards the ground. On a sloping surface at night, the surface tends to
openaire   +1 more source

Sensible heat fluxes by scintillometer and eddy covariance in an irrigated vineyard [PDF]

, 2017
Representative evapotranspiration (ET) measurements over vineyards are today still challenging due to spatial variability of plants, soil conditions and surface topography. In this context, a suitable technique to measure turbulent fluxes is scintillometry, that can give measurement of sensible heat flux at large scale and over heterogeneous surface ...
VENDRAME, NADIA, TEZZA, LUCA, PITACCO, ANDREA   +2 more
openaire   +3 more sources

Surface Heat Source Variations and Driving Factors in Typical Permafrost Areas of the Tibetan Plateau

Remote Sensing
Surface heat sources play a critical role in shaping meteorological conditions and permafrost dynamics on the Tibetan Plateau. To better understand surface heat source variability in the permafrost region, multiyear observational data from an isolated ...
Jimin Yao, Zikang Li, Jie Chen, Lianglei Gu, Ren Li, Tonghua Wu, Xiaodong Wu, Guojie Hu, Yao Xiao, Erji Du, Defu Zou, Guangyue Liu, Guangyang Yue, Yonghua Zhao, Wu Wang, Xiaofan Zhu, Yongping Qiao, Jianzong Shi, Yongjian Ding, Lin Zhao   +19 more
doaj   +1 more source

Annual Observations of Climatic Impacts in the Songhua River Basin, China

Advances in Meteorology, 2015
Heat fluxes have been recognized as determinant regarding the river effect on microclimate. The relationship between rivers and the atmosphere is particularly significant for heat fluxes and varies with the meteorology and hydrology. In this study, based
Xiaocheng Song, Liu Jing
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Inlet Temperature Effects on Sensible Heat Transfer to Falling Liquid Films on Horizontal Round Tubes [PDF]

, 2012
The horizontal-tube, falling film heat exchanger has advantages over flooded bundles and finds widely use in vaporcompression and absorption systems for air-conditioning and refrigeration.
Ruan, Binglu, Jacobi, Anthony M., Li, Huan   +2 more
core   +1 more source