Results 91 to 100 of about 81,196 (301)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Estimation of sensible heat flux over sparsely vegetated surfaces

Journal of Hydrology, 1997
The approach of using remote sensing of surface temperature to estimate spatially distributed surface energy balance components is very attractive. This approach has been applied successfully over surfaces with near full vegetation cover. However, large discrepancies between measured and simulated surface fluxes have been observed over surfaces with ...
Chehbouni, Abdelghani, Lo Seen, D., Njoku, E.G., Lhomme, Jean-Paul, Monteny, Bruno, Kerr, Y.H.   +5 more
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Energy balance on a wheat crop in the southeast of the Buenos Aires province [PDF]

, 2013
Contar con valores observados de radiación neta, de flujos de calor sensible y latente en el aire, y del flujo de calor en el suelo para diversos usos de suelo permite ajustar y validar modelos atmosféricos.
Gassmann, María Isabel, Righetti, Silvina Andrea   +1 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Re-estimation of the vertical sensible heat flux by determining the environmental temperature on a single-point tower measurement

Frontiers in Earth Science
Surface energy balance has always been a goal of those studying the Earth’s climate system. However, many studies have demonstrated that turbulent heat fluxes are usually underestimated by eddy covariance (EC) measurements, such that the energy balance ...
Yongfeng Qi, Yongfeng Qi, Xiaodong Shang, Xiaodong Shang, Guiying Chen, Guiying Chen, Zhiqiu Gao, Xueyan Bi, Linghui Yu, Linghui Yu, Huabin Mao, Huabin Mao   +11 more
doaj   +1 more source

The Summer Surface Energy Budget of the Ice-Free Area of Northern James Ross Island and Its Impact on the Ground Thermal Regime

Atmosphere, 2020
Despite the key role of the surface energy budget in the global climate system, such investigations are rare in Antarctica. In this study, the surface energy budget measurements from the largest ice-free area on northern James Ross Island, in Antarctica,
Klára Ambrožová, Filip Hrbáček, Kamil Láska   +2 more
doaj   +1 more source

The diurnal evolution of the urban heat island of Paris: a model-based case study during Summer 2006 [PDF]

, 2013
The urban heat island (UHI) over Paris during summer 2006 was simulated using the Advanced Regional Prediction System (ARPS) updated with a simple urban parametrization at a horizontal resolution of 1 km.
De Ridder, K., Demuzere, M., Lauwaet, D., van Lipzig, N. P. M., Wouters, H.   +4 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

DINÂMICA DO BALANÇO DE ENERGIA SOBRE O AÇUDE ORÓS E SUAS ADJACÊNCIAS

Revista Caatinga, 2012
This paper aimed to investigate the dynamic of energy balance components over Orós reservoir and neighboring areas using Surface Energy Balance Algorithm for Land (SEBAL) and TM-Landsat 5 images.
FRANCISCO DIRCEU DUARTE ARRAES, EUNICE MAIA DE ANDRADE, BERNARDO BARBOSA DA SILVA   +2 more
doaj