Results 81 to 90 of about 4,665 (266)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Re-estimation of the vertical sensible heat flux by determining the environmental temperature on a single-point tower measurement

Frontiers in Earth Science
Surface energy balance has always been a goal of those studying the Earth’s climate system. However, many studies have demonstrated that turbulent heat fluxes are usually underestimated by eddy covariance (EC) measurements, such that the energy balance ...
Yongfeng Qi, Yongfeng Qi, Xiaodong Shang, Xiaodong Shang, Guiying Chen, Guiying Chen, Zhiqiu Gao, Xueyan Bi, Linghui Yu, Linghui Yu, Huabin Mao, Huabin Mao   +11 more
doaj   +1 more source

The Summer Surface Energy Budget of the Ice-Free Area of Northern James Ross Island and Its Impact on the Ground Thermal Regime

Atmosphere, 2020
Despite the key role of the surface energy budget in the global climate system, such investigations are rare in Antarctica. In this study, the surface energy budget measurements from the largest ice-free area on northern James Ross Island, in Antarctica,
Klára Ambrožová, Filip Hrbáček, Kamil Láska   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

DINÂMICA DO BALANÇO DE ENERGIA SOBRE O AÇUDE ORÓS E SUAS ADJACÊNCIAS

Revista Caatinga, 2012
This paper aimed to investigate the dynamic of energy balance components over Orós reservoir and neighboring areas using Surface Energy Balance Algorithm for Land (SEBAL) and TM-Landsat 5 images.
FRANCISCO DIRCEU DUARTE ARRAES, EUNICE MAIA DE ANDRADE, BERNARDO BARBOSA DA SILVA   +2 more
doaj  

Latent and sensible heat fluxes overestimated and net heat flux underestimated in Lake Victoria

, 2014
1 page, comment to Cozar et al (2012 ...
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Summer soil moisture-convective precipitation coupling in Northern China at different timescales

Journal of Hydrology: Regional Studies
Land-atmosphere coupling plays an important role in regional precipitation and climate change, but the coupling characteristics at different time scales remain controversial.
Hongwei Yang, Zesu Yang, Hang He
doaj   +1 more source

Annual Observations of Climatic Impacts in the Songhua River Basin, China

Advances in Meteorology, 2015
Heat fluxes have been recognized as determinant regarding the river effect on microclimate. The relationship between rivers and the atmosphere is particularly significant for heat fluxes and varies with the meteorology and hydrology. In this study, based
Xiaocheng Song, Liu Jing
doaj   +1 more source