Results 81 to 90 of about 2,191,303 (292)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
The applicability of the scintillation method over heterogeneous areas [PDF]
, 2002 Surface fluxes at a scale of several kilometers are required in many meteorological studies. The scintillation technique is one of the few methods that can provide fluxes at these scales (1 - 10 km).
Kohsiek, W. +2 more
core
A New Approach to Estimating the Sensible Heat Flux in Bare Soils
AtmosphereThe estimation of sensible heat flux (H) in drylands is important because it constitutes a significant portion of the net available surface energy. A model to estimate H half-hourly measurements for bare soils was derived by combining the surface renewal (SR) theory and the Monin–Obukhov similarity theory (MOST), involving the land surface temperature (
Francesc Castellví, Nurit Agam
openaire +3 more sources
Study on Surface Heat Budget of Various Pavements for Urban Heat Island Mitigation
Advances in Materials Science and Engineering, 2012 The surface heat budgets of various pavement surfaces are studied with the aim of mitigating the urban heat island effect. In this study, the thermal characteristics of pavements are examined using data from observations.
Hideki Takebayashi, Masakazu Moriyama
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
A Thin-Film Heat Flux Sensor Fabricated on Copper for Heat Transfer Measurements in Parallel Channel Heat Sinks [PDF]
, 2010 A combination of lithography-based microfabrication and micro end milling is used to manufacture thin-film resistance temperature detector (RTD) heat flux sensors on bulk copper substrates.
Jasperson, Benjamin A. +3 more
core
DINÂMICA DO BALANÇO DE ENERGIA SOBRE O AÇUDE ORÓS E SUAS ADJACÊNCIAS
Revista Caatinga, 2012 This paper aimed to investigate the dynamic of energy balance components over Orós reservoir and neighboring areas using Surface Energy Balance Algorithm for Land (SEBAL) and TM-Landsat 5 images.
FRANCISCO DIRCEU DUARTE ARRAES +2 more
doaj