Results 101 to 110 of about 1,009,466 (301)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Rotation periods and seismic ages of KOIs - comparison with stars without detected planets from Kepler observations

, 2015
One of the most difficult properties to derive for stars is their age. For cool main-sequence stars, gyrochronology relations can be used to infer stellar ages from measured rotation pe- riods and HR Diagram positions.
Ceillier, T., Creevey, O., Garcia, R. A., Mathis, S., Mathur, S., Metcalfe, T. S., Pinsonneault, M. H., Salabert, D., Tayar, J., van Saders, J.   +9 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Seismic noise characterization for the Buddusò–Ala dei Sardi wind park (Sardinia, Italy) and its impact on the Einstein Telescope candidate site [PDF]

Solid Earth
Wind turbines generate considerable seismic noise and interfere with sensitive instruments, such as permanent and temporary seismic sensors installed nearby, hampering their detection capabilities.
G. Diaferia, I. Molinari, I. Molinari, M. Olivieri, M. Olivieri, F. Di Felice, A. Contu, D. D'Urso, D. D'Urso, D. D'Urso, L. Naticchioni, L. Naticchioni, D. Rozza, D. Rozza, J. Harms, J. Harms, A. Cardini, R. De Rosa, R. De Rosa, M. Di Giovanni, M. Di Giovanni, V. Mangano, V. Mangano, F. Ricci, F. Ricci, L. Trozzo, C. Murineddu, C. Giunchi, C. Giunchi   +28 more
doaj   +1 more source

Stellar magnetic activity and Star-Planet Interactions (invited review)

, 2014
Stellar magnetic activity is an important factor in the formation and evolution of exoplanets. Magnetic phenomena like stellar flares, coronal mass ejections, and high-energy emission affect the exoplanetary atmosphere and its mass loss over time.
Poppenhaeger, K.
core   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Refugees and host communities’ vulnerability to climate and disaster risks in Rwanda

Frontiers in Climate
Climate change hazards pose significant risks to vulnerable populations, particularly refugees residing in camps within environmentally sensitive areas. This study assesses climate and disaster risks in refugee-hosting districts in Rwanda using GIS-based
Nfamara K. Dampha, Nfamara K. Dampha, Colette Salemi, Stephen Polasky, Stephen Polasky, Amare Gebre Egziabher, Wendy Rappeport   +6 more
doaj   +1 more source

The Elusive Active Nucleus of NGC 4945 [PDF]

, 2000
We present new HST NICMOS observations of NGC 4945, a starburst galaxy hosting a highly obscured active nucleus that is one of the brightest extragalactic sources at 100 keV.
Macchetto, F., Maiolino, R., Marconi, A., Moorwood, A. F. M., Oliva, E., Schreier, E. J., van der Werf, P. P.   +6 more
core   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source