Results 111 to 120 of about 1,923,064 (277)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Studying the nonlinear mathematical model of the mechanical system “pipeline – pressure sensor”

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. The primary element of the instrumentation for measuring the pressure of a gas-liquid medium is a sensor that supplies data on the pressure of the working medium, which determines the proper functioning of machines, mechanisms, and systems ...
Petr A. Velmisov, Yulia A. Tamarova
doaj   +1 more source

Pulse-width-modulated device for precision temperature control [PDF]

, 1972
Temperature controller is described which reduces difference between temperature oscillations about control point. Standard temperature-sensitive resistor element is utilized which is highly stable and reproducible.
Heyser, R. C.
core   +1 more source

Galerkin Least-Squares Stabilization in Ice Sheet Modeling - Accuracy, Robustness, and Comparison to other Techniques

, 2017
We investigate the accuracy and robustness of one of the most common methods used in glaciology for the discretization of the $\mathfrak{p}$-Stokes equations: equal order finite elements with Galerkin Least-Squares (GLS) stabilization.
Ahlkrona, Josefin, Helanow, Christian
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

CREATION OF NEW ELEMENTS OF SENSOR STRUCTURES OF INFORMATION AND MEASUREMENT SYSTEMS BASED ON SILICON MICROPROCESSING TECHNOLOGIES

Измерение, мониторинг, управление, контроль
Background. The main protective masking layers used in the formation of sensors of information-measurement systems by anisotropic etching of silicon are described. Such layers include films of silicon dioxide and nitride applied to the surface of silicon
A.A. Filatova, V.E. Pautkin, D.V. Trazanov   +2 more
doaj   +1 more source

Jet production rates in association with W and Z bosons in pp collisions at √s = 7 TeV [PDF]

, 2012
Measurements of jet production rates in association with W and Z bosons for jet transverse momenta above 30 GeV are reported, using a sample of proton-proton collision events recorded by CMS at √s = 7TeV, corresponding to an integrated luminosity of 36 ...
Apresyan, A., Bornheim, A., Bunn, J., Chatrchyan, S., Chen, Y., Di Marco, E., Duarte, J., Dubinin, M., Gataullin, M., Ma, Y., Mott, A., Newman, H. B., Rogan, C., Shin, K., Spiropulu, M., Timciuc, V., Traczyk, P., Veverka, J., Wilkinson, R., Yang, Y., Zhu, R. Y.   +20 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source