Results 71 to 80 of about 3,892,337 (243)
Effect of strain softening behaviours on run-out distance of a sensitive clay landslide [PDF]
, 2017 Reliable prediction of landslide triggering threshold and landslide run-out distance is essential for hazard risk assessment. The paper focuses on studying slides in sensitive clays, which represent a major geohazard in many countries including Norway ...
Huynh, Khoa D.V., Fornes, Petter
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроникиCurrently, uncooled thermal detectors are among the most popular photodetectors, since they combine acceptable optical characteristics without the need to maintain the desired temperature. The main advantage of uncooled thermal detectors over cooled ones
A. E. Zhamoit +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Scouting Context-sensitive Components
, 2001 Nature's gadgets are implemented without being planned and therefore can utilize context-sensitive components. Thus functionality that would require extensive networks of context-free components can be elicited from a minimum of material.
Pfaffmann, J. O., Zauner, K.-P.
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Generalized Conforming Quadrilateral Membrane Element Less Sensitive to Geometric Distortion
, 1998 Many finite element models have very acceptable performance when the computing meshes are regular. However, as the level of mesh distortion is increasing, the accuracy of the solutions deteriorates rapidly.
Zhifei Long, Yin Xu, Yuqiu Long
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Simulation of Tensile Stress Concentration Evaluation using Finite Element Performance [PDF]
, 2019 This paper present the investigation on tensile behavior of syntactic foam using finite element analysis (FEA). Tensile properties which is important to discover especially for isotropic materials such syntactic foam.
Epaarachchi, Jayantha +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source