Results 81 to 90 of about 3,892,337 (243)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Research and fabrication of bimetallic plate transducer based on finite element analysis

open access: yesMaterials & Design
By enhancing the type 1–3 piezoelectric composite material, a highly sensitive hydroacoustic transducer sensitive element structure is suggested for uses in sonar systems, such as small target identification and fine imaging.
Yudan Lan   +5 more
doaj   +1 more source

VLSI for microelectronic coordinate-sensitive detector of the devices for element analysis of substance [PDF]

open access: yesTekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2009
VLSI which provides the simultaneous analysis of all composition of substance with a high sensitivity and precision has been developed. VLSI contains 384 detectors with a spatial resolution 25 microns.
Sidorenko V. P.   +4 more
doaj  

Transient Response of a Mass Mounted on a Nonlinear, Strain-Rate Sensitive Element [PDF]

open access: yes, 1959
The object of the present transient movement study was not that of investigation of response of a nonlinear system alone, but was projected to include the effect of a strain-rate sensitive, nonlinear restoring ...
Holmes, Wiley T.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Sensitive review report

open access: yes, 2008
Title from PDF caption (viewed on December 10, 2019).Covers OCLC #1130237092, OCLC #1130236611, and OCLC #1130236422.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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