Results 121 to 130 of about 8,147,464 (347)

Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans [PDF]

, 2017
Amelia Draper, Rebecca M. Koch, J W van der Meer, Matthew A J Apps, Peter Pickkers, Masud Husain, Marieke E. van der Schaaf   +6 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A Sensitivity-Based Algorithm Approach in Reconstructing Images in Electrical Impedance Tomography

IEEE Access
Electrical impedance tomography (EIT) is a medical imaging technique used to reconstruct images inside the domain of interest. EIT collects data on the boundary of the domain to infer the conductivity distribution inside the domain.
Rose Anne D. Alas, Arrianne Crystal T. Velasco   +1 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Evaluation of the Human Immunodeficiency Virus viral load surveillance system, national perspective in Tanzania: A descriptive cross-sectional study

Journal of Interventional Epidemiology and Public Health
Introduction: Human immunodeficiency virus (HIV) infection is still a global public health problem. The number of HIV-positive individuals was estimated to be 38.0 million worldwide in 2020, with 2.78 million being children and adolescents aged 0 to 19 ...
Peter Richard Torokaa, Loveness John Urio, Ambwene Mwakalobo, Alex Sifaeli Magesa, James Njoroge Allan, David John Osima, Focus Medard Shao, Joseph Mziray, Yulitha Barnabas, Agricola Joachim, Mtebe Majigo   +10 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Widespread Sensitivity of Grassland Water Use Efficiency to Deep Soil Moisture on the Tibetan Plateau

Water Resources Research
Water use efficiency (WUE, the ratio of gross primary productivity to evapotranspiration (ET)) is a robust indicator of ecosystem response to climate change, with soil moisture serving as a crucial determinant. Soil moisture varies across soil layers due
Yang Liu, Cheng Chen, Qiuwen Chen, Jianyun Zhang, Zhen Cui, Zhenzhong Zeng   +5 more
doaj   +1 more source

Converters' Loading Balance and Stability Verification for Doubly-Fed Induction Generators

CSEE Journal of Power and Energy Systems
Back-to-back converters are the main components of a doubly-fed induction generator (DFIG). If the loadings of the rotor-side converter (RSC) and the grid-side converter (GSC) are balanced, the capacity and the cost of the DFIG will be reduced.
Shenghu Li
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source