Results 121 to 130 of about 10,108,798 (388)

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.

Proceedings of the National Academy of Sciences of the United States of America, 1986
This report describes the use of fluorescence in situ hybridization for chromosome classification and detection of chromosome aberrations. Biotin-labeled DNA was hybridized to target chromosomes and subsequently rendered fluorescent by successive ...
D. Pinkel, T. Straume, J. Gray
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Consumer price sensitivity in health insurance [PDF]

This CPB Discussion Paper presents new estimates for the price elasticity of the residual demand for health insurance. This elasticity measures the loss in market share of a health insurer as a consequence of a unilateral increase in price, assuming ...
Machiel van Dijk, Marc Pomp, Rudy Douven
core  

WhatIF: R Software for Evaluating Counterfactuals

Journal of Statistical Software, 2005
WhatIf is an R package that implements the methods for evaluating counterfactuals introduced in King and Zeng (2006a) and King and Zeng (2006b). It offers easy-to-use techniques for assessing a counterfactual’s model dependence without having to conduct ...
Heather Stoll, Gary King, Langche Zeng
doaj  

Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis

Di-san junyi daxue xuebao, 2019
Objective To detect the expression of high mobility group box 1 (HMGB1) in hemophagocytic lymphohistiocytosis (HLH) patients and explore its clinical significance in the disease.
CHEN Ying, SUN Hang, LOU Shifeng, ZHOU Kang, ZHANG Ying   +4 more
doaj   +1 more source

Systematic identification of genomic markers of drug sensitivity in cancer cells

Nature, 2012
Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents.
M. Garnett, E. Edelman, S. Heidorn, C. Greenman, A. Dastur, K. Lau, Patricia Greninger, I. R. Thompson, Xi Luo, Jorge Soares, Qingsong Liu, F. Iorio, D. Surdez, Li Chen, R. Milano, G. Bignell, A. T. Tam, Helen R Davies, Jesse A. Stevenson, S. Barthorpe, Stephen R. Lutz, F. Kogera, K. Lawrence, Anne McLaren-Douglas, Xeni Mitropoulos, T. Mironenko, Helen Thi, L. Richardson, Wenjun Zhou, F.E.R. Jewitt, Tinghu Zhang, P. O’Brien, Jessica L. Boisvert, S. Price, W. Hur, Wanjuan Yang, Xianming Deng, A. Butler, H. Choi, J. Chang, J. Baselga, I. Stamenkovic, J. Engelman, Sreenath V. Sharma, O. Delattre, J. Saez-Rodriguez, N. Gray, J. Settleman, P. Futreal, D. Haber, M. Stratton, Sridhar Ramaswamy, U. McDermott, C. Benes   +53 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Neutrino Telescopes' Sensitivity to Dark Matter

, 2002
The nature of the dark matter of the Universe is yet unknown and most likely is connected with new physics. The search for its composition is under way through direct and indirect detection. Fundamental physical aspects such as energy threshold, geometry
A. de Gouvêa, A. Gould, C. Bacci, D.E. Groom, D.J.H. Chung, D.J.H. Chung, D.J.H. Chung, F. Halzen, G. Ingelman, G. Jungman, G. Jungman, G.D. Starkman, G.J. Feldman, George F. Smoot, H.P. Nilles, I.F.M. Albuquerque, I.F.M. Albuquerque, I.F.M. Albuquerque, Ivone F. M. Albuquerque, J. Ahrens, J. Ahrens, J. Edsjo, J. Ellis, J.F. Beacom, J.G. Learned, Jodi Lamoureux, L. Bergstrom, L. Bergstrom, L. Bergstrom, L.K. Resvanis, L.V. Volkova, L.V. Volkova, M. Battaglia, P. Crotty, Q.R. Ahmad, R. Abusaidi, R. Bernabei, R. Gandhi, R. Gandhi, W.H. Press, Y. Fukuda, Y. Fukuda   +41 more
core   +1 more source

Cough Sound Analysis

Acta Medica Martiniana, 2013
Cough is the most common symptom of many respiratory diseases. Currently, no standardized methods exist for objective monitoring of cough, which could be commercially available and clinically acceptable.
Martinek Jozef, Klco P., Vrabec M., Zatko T., Tatar M., Javorka M.   +5 more
doaj   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source