Results 181 to 190 of about 1,766,628 (360)

Sensitivity and specificity

open access: yes, 2015
Matt Morgan   +2 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Reliability of Frozen Section Biopsy in Detecting Endometrial Pathologies: A Systematic Review of Sensitivity and Specificity. [PDF]

open access: yesCureus
Ali Mohammed MA   +5 more
europepmc   +1 more source

Effect of varying sensitivity and specificity of the nLRDT for Scenario 1 and Scenario 2.

open access: green
Aren Sargood (22513356)   +3 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

Sensitivity and specificity of the neutrophil-to-lymphocyte ratio for predicting mortality in patients with non-metastatic acral melanoma. [PDF]

open access: yesJAAD Int
Pallares CNC   +5 more
europepmc   +1 more source

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