Results 181 to 190 of about 4,361,080 (379)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Correlation between hearing loss and the results of the following questionnaires: Hearing Handicap Inventory for the Adults - Screening Version HHIA-S and Hearing Handicap Inventory for the Elderly - Screening Version - HHIE-S

open access: yesInternational Archives of Otorhinolaryngology, 2011
Introduction: The self-assessment questionnaires are useful to measure the emotional and social/transient consequences resulting from hearing loss, and they can be used in a wide range of situations in the clinical routine, such as auditory screening ...
Menegotto, Isabela Hoffmeister   +3 more
doaj  

Selective Forgetting: Advancing Machine Unlearning Techniques and Evaluation in Language Models [PDF]

open access: yesarXiv
This paper explores Machine Unlearning (MU), an emerging field that is gaining increased attention due to concerns about neural models unintentionally remembering personal or sensitive information. We present SeUL, a novel method that enables selective and fine-grained unlearning for language models.
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Bridging the Gap Between Design and Analysis: Randomization Inference and Sensitivity Analysis for Matched Observational Studies with Treatment Doses [PDF]

open access: yesarXiv
Matching is a commonly used causal inference study design in observational studies. Through matching on measured confounders between different treatment groups, valid randomization inferences can be conducted under the no unmeasured confounding assumption, and sensitivity analysis can be further performed to assess sensitivity of randomization ...
arxiv  

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

open access: yesMolecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana   +17 more
wiley   +1 more source

Whole‐genome sequencing of cell‐free DNA reveals DNA of tumor origin in plasma from patients with colorectal adenomas

open access: yesMolecular Oncology, EarlyView.
Tumor‐informed whole‐genome sequencing (MRD‐EDGESNV) was applied to detect circulating tumor DNA (ctDNA) in patients with colorectal adenomas. Using a 95% specificity threshold, established from stage III colorectal cancer patients, ctDNA was detected in 50% of symptomatic and 25% of asymptomatic adenoma cases with median tumor fractions of 5.9 × 10−5 ...
Amanda Frydendahl   +13 more
wiley   +1 more source

Sensitivity and specificity of the trichoscopy

open access: yesIndian Journal of Dermatology, Venereology, and Leprology, 2012
Elzbieta Kowalska-Oledzka   +2 more
openaire   +3 more sources

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