Results 211 to 220 of about 1,766,628 (360)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location. [PDF]

J Clin Microbiol
Van Der Pol B, Arcenas R, Boraas C, Chavoustie S, Crane LL, d'Empaire N, Ermel AC, Harnett G, Hinestrosa F, House S, Lillis RA, Miller J, Mills A, Poblete R, Young SA, Liat CT/NG/MG Clinical Trial Study Group.   +15 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Calculation of Sensitivity and Specificity from Partial Data for Meta-Analyses: Introducing Some Practical Methods. [PDF]

Arch Acad Emerg Med
Khatami R, Faghihi M, Khatami H, Yousefifard M, Khatami S.   +4 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Diagnosis of Trypanosoma cruzi infection in Mexican populations: current conventional serology lacks adequate sensitivity and specificity. [PDF]

Mem Inst Oswaldo Cruz
Ramsey JM, de la Cruz-Felix K, Tun-Ku E, Schijman AG, Gutiérrez S, Virgen-Cuevas M, Reyes-Romero M, Escobedo-López K, Sánchez-González G, Pech-May A.   +9 more
europepmc   +1 more source

(a) Forest plot of the sensitivity and specificity of Xpert for tuberculosis detection compared with a composite reference standard. (b) Forest plot of the sensitivity and specificity of Xpert for tuberculosis detection compared with the culture reference standard. The squares represent the sensitivity and specificity of a study, and the black line represents their confidence intervals. The diamonds represent the pooled sensitivity and specificity and their confidence intervals.

Zi-Ke Chen (21262189), Zhao Wu (3443963), Ting Ye (346594), Chao-Yang Lin (1626865), Xu-Guang Guo (10581669)   +4 more
openalex   +1 more source

High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort [PDF]

Katherine Gong, Jigyasha Timsina, Muhammad Junaid Ali, Yike Chen, Menghan Liu, Ciyang Wang, Cyril Pottier, Geoffrey K. Feld, Gyujin Heo, Tammie L.S. Benzinger, Cyrus A. Raji, Beau M. Ances, Brian A. Gordon, Julie K. Wisch, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Laura Ibáñez, Carlos Cruchaga   +18 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source