Results 61 to 70 of about 88,292 (194)

Psychometric Properties of Persian Version of Checklist for Autism in Toddlers (CHAT)

مجله دانشکده پزشکی اصفهان, 2019
Background: The increasing rate of autism spectrum disorder highlights the need for early screening with the aim to provide early intervention. This study aimed to provide Persian version of Checklist for Autism in Toddlers (CHAT) and assess its ...
Amrollah Ebrahimi, Fereshteh Shakibaei, Ali Reza Mohseni, Zahra Khayyer, Elnaz Pishghadam, Hamid Nasiri-Dehsorkhi   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diagnostic Performance of Arm Circumference Compared to Other Indicators for Detecting Sarcopenia in Older Adults [PDF]

Annals of Geriatric Medicine and Research
Background To evaluate the accuracy of arm circumference (AC) compared with other anthropometric and functional indicators as a predictor of sarcopenia risk in community-dwelling older adults.
Brena Leticia Gomes de Paiva, Claudia Porto Sabino Pinho Ramiro, Cyro Rego Cabral Junior, Fabiana Andrea Moura, Enaiane Cristina Menezes, Gabriel Soares Bádue, Müller Ribeiro-Andrade, João Araújo Barros-Neto   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Screening Characteristics of Ultrasonography in Detection of Ankle Fractures

Archives of Academic Emergency Medicine, 2018
Introduction: Ankle fracture is one of the most common joint fractures. X-ray and physical examination are its main methods of diagnosis. Recently, ultrasonography (US) is considered as a simple and non-invasive method of fracture diagnosis.
Majid Shojaee, Farhad Hakimzadeh, Parisa Mohammadi, Anita Sabzghabaei, Mohammad Manouchehrifar, Ali Arhami Dolatabadi   +5 more
doaj   +1 more source

Mechanisms of Sensitivity and Specificity in Olfaction

Cold Spring Harbor Symposia on Quantitative Biology, 1992
The sensitivity and specificity of the mammalian olfactory system is the result of the contributions at the anatomical, cellular, and biochemical levels. The recent identification of a large gene family encoding putative olfactory receptors suggests that genetic diversity may play an important role in this system. Future challenges lie in understanding
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Sensitive and Specific Bioassay for Oxytocin

Experimental Biology and Medicine, 1970
SummaryA method for quantitative assay of oxytocin using strips from the mammary gland of lactating mice has been studied. The method is suitable for determinations of small amounts of oxytocin. Doses as small as 10 μU/ml can be estimated. The precision of the method is high and it is highly specific.
C, Fielitz, R, Roca, A, Mattei, S, Melander, E, Garófalo, M N, Gioia de Coch, J A, Coch   +6 more
openaire   +2 more sources