Results 91 to 100 of about 867,779 (267)

Oscillation energy based sensitivity analysis and control for multi-mode\n oscillation systems [PDF]

, 2017
Horacio Silva-Saravia, Yajun Wang, Héctor Pulgar-Painemal, Kevin Tomsovic   +3 more
openalex   +1 more source

FINDING DEFECTS IN AUTOMATIC CONTROL SYSTEMS BASED ON STRUCTURE SENSITIVITY FUNCTIONS AND ANALYSIS OF INTEGRAL ESTIMATES OF OUTPUT SIGNALS

, 2021
Sergey V. Shalobanov, S.S. Shalobanov, A. A. Aleksandrov   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Stability Improvement Method for Multi-Converter Distribution Systems Based on Impedance Sensitivity

CSEE Journal of Power and Energy Systems
This paper uses impedance sensitivity to identify the parameters that have dominant influences on the stability of multi-converter systems, which can then efficiently improve system stability.
Yang Li, Zhikang Shuai, Junbin Fang, Xiangyang Wu   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dynamic sensitivity analysis of biological systems

BMC Bioinformatics, 2008
Background A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is always modeled as a nonlinear ordinary differential equation (ODE) system.
Chang Maw, Wang Feng, Wu Wu
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A robust regional eigenvalue assignment problem using rank-one control for undamped gyroscopic systems

AIMS Mathematics
Considering the advantages of economic benefit and cost reduction by using rank-one control, we investigated the problem of robust regional eigenvalue assignment using rank-one control for undamped gyroscopic systems. Based on the orthogonality relation,
Binxin He, Hao Liu
doaj   +1 more source

Controlling arrival and service rates to reduce sensitivity of queueing systems with customer abandonment [PDF]

, 2021
Katsunobu Sasanuma, Robert C. Hampshire, Alan Scheller‐Wolf   +2 more
openalex   +1 more source