Results 101 to 110 of about 5,977,029 (374)

Risk-sensitive control of cash management systems

open access: yesOperational Research, 2017
[EN] Firms manage cash for operational, precautionary and speculative purposes. Stat-of-the-art cash management models usually focus on cost minimization by means of a set of controlling bounds. In this paper, we propose a multiobjective model to control cash management systems with multiple accounts characterized by generalized cash flow processes. In
openaire   +3 more sources

A Novel Voltage Sensitivity Approach for the Decentralized Control of DG Plants

open access: yesIEEE Transactions on Power Systems, 2018
Renewable distributed generation (DG) is likely to be actively controlled in future distribution networks to mitigate voltage issues resulting from high penetrations.
Zedong Zhang, L. Ochoa, G. Valverde
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

When do Trajectories have Bounded Sensitivity to Cumulative Perturbations? [PDF]

open access: yesarXiv, 2019
We investigate sensitivity to cumulative perturbations for a few dynamical system classes of practical interest. A system is said to have bounded sensitivity to cumulative perturbations (bounded sensitivity, for short) if an additive disturbance leads to a change in the state trajectory that is bounded by a constant multiple of the size of the ...
arxiv  

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

open access: yesMolecular Oncology, EarlyView.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso   +12 more
wiley   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

open access: yesMolecular Oncology, EarlyView.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang   +6 more
wiley   +1 more source

Sensitivity Analysis and Distribution Factor Calculation under Power Network Branch Power Flow Exceedance

open access: yesEnergies
As the scale of power systems continue to expand and their structure becomes increasingly complex, it is likely that branch power flow exceedance may occur during the operation of power systems, posing threats to the safe and stable operation of entire ...
Shuqin Sun   +4 more
doaj   +1 more source

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