Results 51 to 60 of about 2,433,822 (346)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

An Easily Understandable Grey Wolf Optimizer and Its Application to Fuzzy Controller Tuning

open access: yesAlgorithms, 2017
This paper proposes an easily understandable Grey Wolf Optimizer (GWO) applied to the optimal tuning of the parameters of Takagi-Sugeno proportional-integral fuzzy controllers (T-S PI-FCs). GWO is employed for solving optimization problems focused on the
Radu-Emil Precup   +4 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Nonnormality and the localized control of extended systems

open access: yes, 2002
The idea of controlling the dynamics of spatially extended systems using a small number of localized perturbations is very appealing - such a setup is easy to implement in practice.
Andreas Handel   +7 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

IDENTIFICATION OF REFUSALS OF CONTROL SYSTEMS OF AIRCRAFTS BY MEANS OF SENSITIVITY FUNCTIONS

open access: yesНаучный вестник МГТУ ГА, 2016
Article is devoted to detection and identification of refusals of governing bodies like "withdrawal and a klineniye" in ideal statement (the atmosphere - not indignant, sensors - ideal). Relevance of consideration of the matters is caused by a problem of
A. D. Barabash, I. N. Merzlikin
doaj  

Expanding biological control to bioelectronics with machine learning

open access: yesAPL Materials, 2020
Bioelectronics integrates electronic devices and biological systems with the ability to monitor and control biological processes. From homeostasis to sensorimotor reflexes, closed-loop control with feedback is a staple of most biological systems and ...
J. Selberg   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Automatic Control System of the Evaporator in the Technology of Spent Nuclear Fuel Processing

open access: yesChemical Engineering Transactions, 2017
The operation of the radiochemical plant is impossible without high-quality automatic control systems. In the technologies of spent nuclear fuel reprocessing, the method of continuous evaporation is often used for a solution conditioning.
A.V. Vilnina   +5 more
doaj   +1 more source

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