Results 71 to 80 of about 5,418,166 (357)
BiosensorsIndustrially applied bioelectrochemical systems require long-term stable operation, and hence the control of biofilm accumulation on the electrodes. An optimized application of biofilm control mechanisms presupposes on-line, in-situ monitoring of the ...
Andreas Netsch +3 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Differential Sensitivity and Control System Structures
IFAC Proceedings Volumes, 1993 Abstract Sensitivity functions are useful for investigating and improving existing controllers. Several control structures that are suited for the design of low-sensitivity control systems are presented. The performance of selected low-sensitivity controllers are investigated both in simulation and experimentation.
O.C. Ramambason, D. Bonvin
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
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An Easily Understandable Grey Wolf Optimizer and Its Application to Fuzzy Controller Tuning
Algorithms, 2017 This paper proposes an easily understandable Grey Wolf Optimizer (GWO) applied to the optimal tuning of the parameters of Takagi-Sugeno proportional-integral fuzzy controllers (T-S PI-FCs). GWO is employed for solving optimization problems focused on the
Radu-Emil Precup +4 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
MathematicsIn control systems, chaos is a natural dualistic phenomenon that can be both a beneficial resource to be used and a negative phenomenon to be avoided. The study examines two opposing paradigms: positive chaotic control, which aims to enhance performance,
Asad Shafique +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Sensitivity driven experimental design to facilitate control of dynamical systems [PDF]
, 2022 Joseph Hart +3 more
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FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source