Results 61 to 70 of about 1,129,627 (263)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Derivative based sensitivity analysis of gamma index
Journal of Medical Physics, 2015 Originally developed as a tool for patient-specific quality assurance in advanced treatment delivery methods to compare between measured and calculated dose distributions, the gamma index (γ) concept was later extended to compare between any two dose ...
Biplab Sarkar, Anirudh Pradhan, T Ganesh
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Construction of index system for nursing sensitivity of prone position ventilation in ICU patients
Huli yanjiu, 2020 ObjectiveTo construct the index system for nursing sensitivity of prone position ventilation in ICU patients based on the Donabedian model,so as to provide theoretical basis for evaluating the nursing quality of prone position ventilation.MethodsGuided ...
LANG Zijia, WANG Liping
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Indexicals, context-sensitivity and the failure of implication
Synthese, 2010 This paper investigates, formulates and proves an indexical barrier theorem, according to which sets of non-indexical sentences do not entail (except under specified special circumstances) indexical sentences. It surveys the usual difficulties for this kind of project, as well some that are specific to the case of indexicals, and adapts the strategy of
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Process Capability and Data Contamination
Kvalita Inovácia Prosperita, 2017 Purpose: The paper centres on process capability and its relation to data contamination. Process capability may be distorted due to imprecise data. The paper analyses to what extent capability changes reflect problems in data so that the changes can be
Filip Tošenovský, Josef Tošenovský
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Symptoms specificity of anxiety sensitivity dimensions in Korean adults
Indian Journal of Psychological Medicine, 2014 Context: Relation of three dimensions of anxiety sensitivity (AS) (physical concerns [PC], cognitive concerns [CC] and social concerns [SC]) with anxiety or depression has been inconsistently reported.
Young-Jin Lim
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