Results 91 to 100 of about 735,970 (407)

Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole‐size spatially fractionated radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose/objective We propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high‐dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high‐dose spheres.
Joshua Misa, William St. Clair, Damodar Pokhrel   +2 more
wiley   +1 more source

A Survey of Preservatives Used in Cosmetic Products

Applied Sciences
The aim of this study was to indicate the type of preservatives used in selected categories of cosmetic products sold in Poland (part of the EU market) and determine the frequency of their use. The tested products consisted of 200 leave-on cosmetics, viz.
Patrycja Poddębniak, Urszula Kalinowska-Lis   +1 more
doaj   +1 more source

Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation

Frontiers in Systems Neuroscience, 2014
Methamphetamine (MA) is a highly addictive psychomotor stimulant, with life-time prevalence rates of abuse ranging from 5-10% world-wide. Yet, a paucity of research exists regarding MA addiction vulnerability/resiliency and neurobiological mediators of ...
Kevin D Lominac, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh eRajasekar, Dan eMaliniak, Andrew B Thompson, Lawrence E Urman, Tamara ePhillips, Karen K Szumlinski   +13 more
doaj   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Pretransplant, Th17 dominant alloreactivity in highly sensitized kidney transplant candidates

Frontiers in Transplantation
IntroductionSensitization to donor human leukocyte antigen (HLA) molecules prior to transplantation is a significant risk factor for delayed access to transplantation and to long-term outcomes.
Sarita Negi, Sarita Negi, Alissa K. Rutman, Chee Loong Saw, Steven Paraskevas, Steven Paraskevas, Steven Paraskevas, Steven Paraskevas, Jean Tchervenkov, Jean Tchervenkov, Jean Tchervenkov   +10 more
doaj   +1 more source

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

Journal of Neuroscience, 2008
Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries, plays an essential role in the induction and maintenance of chronic pain. However, synaptic mechanisms underlying central sensitization are incompletely known.
Y. Kawasaki, Ling Zhang, Jen-Kun Cheng, R. Ji   +3 more
semanticscholar   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?

Frontiers in Psychiatry
Under conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed, Cheryl Reed, Tamara J. Phillips, Tamara J. Phillips, Tamara J. Phillips   +4 more
doaj   +1 more source

Repeated Cocaine Exposure Attenuates the Desire to Actively Avoid: A Novel Active Avoidance Runway Task

Frontiers in Behavioral Neuroscience, 2018
Drug addiction is a disorder in which drug seeking persists despite aversive consequences. While it is well documented in animal models of drug sensitization that repeated drug exposure enhances positive incentive motivation for drug and natural ...
David Nguyen, Yasika Nesarajah, Suzanne Erb, Suzanne Erb, Rutsuko Ito, Rutsuko Ito   +5 more
doaj   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source