Results 111 to 120 of about 222,573 (269)
Correlation of Aspergillus fumigatus Sensitization with Mucus Plugging in COPD [PDF]
Ying Luo,1,2 Jiaqi Ren,1,2 Long Liang,1,2 Jingge Qu,1,2 Chun Chang,1,2 Yongchang Sun1,2 1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, People’s Republic of China; 2Research Center for Chronic Airway ...
Ren J +5 more
core +1 more source
Digital Twin of a One‐Sun‐Driven Luminescent‐Concentrator‐Assisted Planar Solar‐Pumped Fiber Laser
Advanced Optical Materials, EarlyView.An experimentally‐validated digital twin of a one‐sun solar‐pumped fiber laser enables a design exhibit 13‐times higher output power at 1064 nm to be achieved. Despite its simple appearance, the multitude of choices in the design parameters make finding this improved very tedious in the lab, thus the digital twin can save significant time and effort ...
Anvarjon Sherniyozov +2 more
wiley +1 more source
Advanced Optical Materials, EarlyView.Introducing a 5‐phenylbenzo[b]thiophene unit into the DABNA core lowers the T1 level, enlarging the ΔEST to suppress TADF. This molecular design preserves narrow deep‐blue emission while drastically reducing triplet‐related degradation. Consequently, the resulting emitter, BN‐TPh‐TPA, delivers a threefold operational lifetime over the TADF‐active t ...
Jihun Hwang +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Toluene diisocyanate (TDI) is a leading cause of chemical-induced occupational asthma which impacts workers in a variety of industries worldwide. Recently, the robust regulatory potential of regulatory T cells (Tregs) has become apparent, including their
core
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang +7 more
wiley +1 more source
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source