Results 91 to 100 of about 265,697 (314)
Sensitiveness of the Peritoneum [PDF]
The American Journal of the Medical Sciences, 1901 n ...
openaire +2 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Edible Insects and Allergy Risks: Implications for Children and the Elderly
AllergiesPopulation growth and the depletion of natural resources have driven the incorporation of edible insects into the human food matrix. Despite their high nutritional value and the environmental benefits of insect farming compared to conventional protein ...
Alessandra de Cássia Romero
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Characterization of Adolescent and Adult Ethanol Sensitization [PDF]
, 2008 Alcoholism is a serious health problem that affects the lives of millions of people worldwide. People that first experiment with alcohol as adolescents are at a greater risk to become alcoholics.
Stevenson, Rebekah Ann
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Allergic sensitization among Danish infants at 13 months of age
Immunity, Inflammation and Disease, 2019 Background Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.
Lisbeth M. Thøstesen +1 more
doaj +1 more source
Nitric Oxide-Mediated Enhancement and Reversal of Resistance of Anticancer Therapies
Antioxidants, 2019 In the last decade, immune therapies against human cancers have emerged as a very effective therapeutic strategy in the treatment of various cancers, some of which are resistant to current therapies.
Emily Hays, Benjamin Bonavida
doaj +1 more source
Structural differences between high- and low-sensitization responders.
, 2015 Volumes of caudate nuclei are shown as a function of secondary hyperalgesia areas in high-sensitization responders (red triangles) and low-sensitization responders (blue diamonds).
Henrik B. W. Larsson (468244) +5 more
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source