PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]
, 2018 The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon +2 more
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Allergic sensitization among Danish infants at 13 months of age
Immunity, Inflammation and Disease, 2019 Background Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.
Lisbeth M. Thøstesen +1 more
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Nitric Oxide-Mediated Enhancement and Reversal of Resistance of Anticancer Therapies
Antioxidants, 2019 In the last decade, immune therapies against human cancers have emerged as a very effective therapeutic strategy in the treatment of various cancers, some of which are resistant to current therapies.
Emily Hays, Benjamin Bonavida
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Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects [PDF]
, 2013 Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which ...
A Ashkenazi +46 more
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Doubling your payoff: winning pain relief engages endogenous pain inhibition [PDF]
, 2015 When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience (“liking”) of a reward by the motivation to obtain a reward (“wanting”), the seeking of pain relief in ...
Ahmed, Alysha-Karima +4 more
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JHLT OpenBackground: Little is known about de novo human luekocyte antigen (HLA) antibody development with Impella 5.5 temporary mechanical circulatory assist support and downstream effects following heart transplantation in the new heart allocation system ...
Amit Alam, MD +9 more
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Behavioral Treatment Approaches to Obesity: Successes with the Nonretarded and Retarded [PDF]
, 1981 This article discusses the successful use of behavioral approaches, which have been adopted from research with non-retarded individuals, to the treatment of obese retarded individuals.
Fox, Robert A. +2 more
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Basic and Clinical Neuroscience, 2020 Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance
Amir Abbas Barzegari, Kamran Shahabi
doaj
Assessment of the Degree of Allergenic Effects of Various Drugs of Francisella tularensis
Эпидемиология и вакцинопрофилактика, 2017 The evaluation of sensitization conducted on guinea pig leukocytes immunized with the cell wall preparations of F. tularensis. In this research was shown that the cell wall preparations F tularensis subsp mediaasiatica A-61 and F tularensis subsp ...
T. P. Starovoitova +6 more
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From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]
, 2017 OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia +3 more
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