Results 71 to 80 of about 265,697 (314)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
HLA Mismatching Strategies for Solid Organ Transplantation - a Balancing Act
Frontiers in Immunology, 2016 HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression.
Andrea A. Zachary, Mary S Leffell
doaj +1 more source
Synthese, 2010 In this paper, I argue that there are good motivations for a relativist account of the domain-sensitivity of quantifier phrases. I will frame the problem as a puzzle involving what looks like a logically valid inference, yet one whose premises are true while the conclusion is false. After discussing some existing accounts, literalist and contextualist,
openaire +3 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Functional differences in airway dendritic cells determine susceptibility to IgE-sensitization [PDF]
, 2018 Respiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma. Dendritic cells (DC) residing in the airways orchestrate the immune response following antigen exposure and their ability to sample ...
Strickland, Deborah H +27 more
core +1 more source
"THE SENSITIVENESS OF THE PERITONEUM." [PDF]
The Lancet, 1893 n ...
Sherrington, C. S., Littlewood, H.
openaire +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 2011 Respiratory syncytial virus (RSV) bronchiolitis in early life is a risk factor for later development of asthma and atopy. Ribavirin is the only effective drug currently available against acute RSV bronchiolitis.
陳建翰;林于粲;楊曜旭;王麗潔;李志鴻;高全良;江伯倫 +1 more
core +1 more source
Concomitant sensitization to glutaraldehyde and methacrylic monomers among dentists and their patients [PDF]
, 2016 Background: A multitude of methacrylic monomers is used in dentistry. Glutaraldehyde (G) is used in dental practice and consumer products as a broad-spectrum antimicrobial agent.
Assya Krasteva-Panova +12 more
core +2 more sources
Constructions of sensitive graphs which are not strongly sensitive
Discrete Mathematics, 1988 Let \(G\) be a simple graph with vertex set \(V(G)\) and edge set \(E(G)\). For each \(a\) in \(V(G)\), let \(N(a)=\{x\in V(G): ax\in E(G)\}\) be the set of neighbours of \(a\). A subset \(S\) of \(V(G)\) is called a closed set of \(G\) if, for each pair of distinct elements \(a\), \(b\) in \(S\), \(N(a)\cap N(b)\subseteq S\).
Koh, K.M., Poh, K.S.
openaire +3 more sources