Results 61 to 70 of about 265,697 (314)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Crystals, 2022 A Ni-Cr-Mo-based C276 superalloy was cold rolled to 5–40% and annealed at 1050 °C for 30 min. The microstructure and grain boundary character distribution after cold rolling and annealing were characterized.
Chi Zhang +4 more
doaj +1 more source
, 1967 A new treatment for maladaptive approach behavior (“covert sensitization”) is described. The term “covert” is used because neither the undesirable stimulus nor the aversive stimulus is actually presented. These stimuli are presented in imagination only.
Joseph R. Cautela
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
ChemistryTitanium dioxide (TiO2) thin films sensitized with curcumin were fabricated to investigate the influence of sensitization on their spectroscopic, optical, and photocatalytic properties. TiO2 films were prepared using different curcumin concentrations and
William Vallejo +6 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
BiomedicinesBackground: Since the discovery of successful direct-acting antiviral (DAA) treatment, kidneys from hepatitis C virus (HCV) RNA-positive donors represent a new opportunity to expand the organ donor pool for HCV-negative recipients.
Tanja Belčič Mikič +3 more
doaj +1 more source
Brain mechanisms of short-term habituation and sensitization towards dyspnea
Frontiers in Psychology, 2015 Dyspnea is a prevalent and threatening cardinal symptom in many diseases including asthma. Whether patients suffering from dyspnea show habituation or sensitization towards repeated experiences of dyspnea is relevant for both quality of life and ...
M Cornelia Stoeckel +5 more
doaj +1 more source
Specific Immunotherapy in a Murine Model of Grass Pollen (Phl p5b)-Induced Airway Inflammation
Frontiers in Allergy, 2021 Background: The use of ovalbumin as a model allergen in murine models of allergic asthma is controversially discussed since it is not an aeroallergen and sensitization can only be achieved by using strong Th2-inducing adjuvants. Therefore, in this study,
Matthias Stiehm, Marcus Peters
doaj +1 more source
International Journal of Neuropsychopharmacology / Making Sense of : Sensitization in Schizophrenia
, 2016 Sensitization is defined as a process whereby repeated intermittent exposure to a given stimulus results in an enhanced response at subsequent exposures. Next to robust findings of an increased dopamine synthesis capacity in schizophrenia, empirical data
Weidenauer, Ana +15 more
core +1 more source